Invitrogen

RAB11A/RAB11B Polyclonal Antibody

View all (5) RAB11A/RAB11B antibodies

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-120704

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RAB11A/RAB11B (NP_0046541)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.507 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2914276

Product Specific Information

Positive test controls include: A-549, Mouse brain, Mouse heart, Rat liver, Rat heart.

Immunogen sequence: MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT RSIQVDGKTI KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE

Target Information

Rab11A is a member of the YPT-1 subfamily of Ras-related GTP-binding proteins. Rab11A mRNA has been detected in a variety of tissues including brain, testis, spleen, heart, and gastrointestinal mucosa. In the gastric fundus the Rab11A protein is expressed in parietal cell tubulovesicles membranes. Expression of the Rab11A protein appears to occur in discrete epithelial cell populations where it localizes to apical vesicular populations. Recent studies have shown Rab11A is essential for resecretion of alpha-synuclein out of neuronal cells via endosome recycling and is required for exocytosis of discoidal/fusiform vesicles of bladder umbrella cells. Rab11A is also implicated in biogenesis of Birbeck granules and endosomal activation of the PI3K/AKT signaling pathway via G beta gamma trafficking.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 24KG; GTP-binding protein YPT3; RAB 11A, member oncogene family; Rab-11; RAB11B, member of RAS oncogene family; RAS oncogene family protein; Ras-related protein Rab-11A; Ras-related protein Rab-11B; YL8

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Gene Aliases: A730055L17Rik; H-YPT3; RAB11; RAB11A; RAB11B; YL8; YPT3

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UniProt ID: (Human) P62491, (Human) Q15907, (Rat) P62494, (Mouse) P62492, (Rat) O35509, (Mouse) P46638

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Entrez Gene ID: (Human) 8766, (Human) 9230, (Rat) 81830, (Mouse) 53869, (Rat) 79434, (Mouse) 19326

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Function(s)
GTPase activity protein binding GTP binding microtubule binding syntaxin binding myosin V binding GDP binding cadherin binding involved in cell-cell adhesion nucleotide binding
Process(es)
intracellular protein transport exocytosis mitotic metaphase plate congression metabolic process positive regulation of epithelial cell migration regulation of multivesicular body size positive regulation of G2/M transition of mitotic cell cycle vesicle-mediated transport astral microtubule organization neuron projection development melanosome transport Rab protein signal transduction multivesicular body assembly positive regulation of axon extension regulation of long-term neuronal synaptic plasticity regulation of protein transport establishment of vesicle localization regulation of vesicle-mediated transport establishment of protein localization to organelle protein localization to plasma membrane establishment of protein localization to membrane mitotic spindle assembly exosomal secretion receptor recycling small GTPase mediated signal transduction transferrin transport insulin secretion involved in cellular response to glucose stimulus regulation of anion transport constitutive secretory pathway regulated exocytosis cellular response to acidic pH cell-cell adhesion retrograde transport, endosome to plasma membrane regulation of protein localization to cell surface regulation of endocytic recycling endocytosis cytokinesis renal water homeostasis protein transport plasma membrane to endosome transport transport cell cycle
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