Proteintech

RAB39B Polyclonal Antibody

RAB39B Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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RAB39B Antibody (12162-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human lymphoma using 12162-1-AP (RAB39B antibody) at dilution of 1:50 (under 10x lens).

RAB39B Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12162-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RAB39B Fusion Protein Ag2803 (1-213 aa encoded by BC009714)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MEAIWLYQF RLIVIGDSTV GKSCLIRRFT EGRFAQVSDP TVGVDFFSRL VEIEPGKRIK LQIWDTAGQE RFRSITRAYY RNSVGGLLLF DITNRRSFQN VHEWLEETKV HVQPYQIVFV LVGHKCDLDT QRQVTRHEAE KLAAAYGMKY IETSARDAIN VEKAFTDLTR DIYELVKRGE ITIQEGWEGV KSGFVPNVVH SSEEVVKSER RCLC (1-213 aa encoded by BC009714)

Target Information

This gene encodes a member of the Rab family of proteins. Rab proteins are small GTPases that are involved in vesicular trafficking.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Increased level of RAB39B leads to neuronal dysfunction and behavioural changes in mice.

Journal of cellular and molecular medicine

Wang Z,Niu M,Zheng N,Meng J,Jiang Y,Yang D,Yao P,Yao T,Luo H,Xu H,Ge Y,Zhang YW,Zhang X

Mon May 01 00:00:00 UTC 2023

RAB39B is redistributed in dementia with Lewy bodies and is sequestered within aβ plaques and Lewy bodies.

Brain pathology (Zurich, Switzerland)

Koss DJ,Bondarevaite O,Adams S,Leite M,Giorgini F,Attems J,Outeiro TF

Fri Jan 01 00:00:00 UTC 2021

RAB39B is redistributed in dementia with Lewy bodies and is sequestered within aβ plaques and Lewy bodies.

Brain pathology (Zurich, Switzerland)

Koss DJ,Bondarevaite O,Adams S,Leite M,Giorgini F,Attems J,Outeiro TF

Fri Jan 01 00:00:00 UTC 2021

Distribution of Parkinson's disease associated RAB39B in mouse brain tissue.

Molecular brain

Gao Y,Wilson GR,Stephenson SEM,Oulad-Abdelghani M,Charlet-Berguerand N,Bozaoglu K,McLean CA,Thomas PQ,Finkelstein DI,Lockhart PJ

Mon Mar 30 00:00:00 UTC 2020

Distribution of Parkinson's disease associated RAB39B in mouse brain tissue.

Molecular brain

Gao Y,Wilson GR,Stephenson SEM,Oulad-Abdelghani M,Charlet-Berguerand N,Bozaoglu K,McLean CA,Thomas PQ,Finkelstein DI,Lockhart PJ

Mon Mar 30 00:00:00 UTC 2020

RAB39B Deficiency Impairs Learning and Memory Partially Through Compromising Autophagy.

Frontiers in cell and developmental biology

Niu M,Zheng N,Wang Z,Gao Y,Luo X,Chen Z,Fu X,Wang Y,Wang T,Liu M,Yao T,Yao P,Meng J,Zhou Y,Ge Y,Wang Z,Ma Q,Xu H,Zhang YW

Tue Dec 29 00:00:00 UTC 2020

Clinical and Neuropathological Features Associated With Loss of RAB39B.

Movement disorders : official journal of the Movement Disorder Society

Gao Y,Martínez-Cerdeño V,Hogan KJ,McLean CA,Lockhart PJ

Wed Apr 01 00:00:00 UTC 2020

Synaptic localization of C9orf72 regulates post-synaptic glutamate receptor 1 levels.

Acta neuropathologica communications

Xiao S,McKeever PM,Lau A,Robertson J

Thu Oct 24 00:00:00 UTC 2019

Synaptic localization of C9orf72 regulates post-synaptic glutamate receptor 1 levels.

Acta neuropathologica communications

Xiao S,McKeever PM,Lau A,Robertson J

Thu Oct 24 00:00:00 UTC 2019

Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.

The EMBO journal

Sellier C,Campanari ML,Julie Corbier C,Gaucherot A,Kolb-Cheynel I,Oulad-Abdelghani M,Ruffenach F,Page A,Ciura S,Kabashi E,Charlet-Berguerand N

Wed Jun 15 00:00:00 UTC 2016

Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.

The EMBO journal

Sellier C,Campanari ML,Julie Corbier C,Gaucherot A,Kolb-Cheynel I,Oulad-Abdelghani M,Ruffenach F,Page A,Ciura S,Kabashi E,Charlet-Berguerand N

Wed Jun 15 00:00:00 UTC 2016

Mutations in RAB39B cause X-linked intellectual disability and early-onset Parkinson disease with α-synuclein pathology.

American journal of human genetics

Wilson GR,Sim JC,McLean C,Giannandrea M,Galea CA,Riseley JR,Stephenson SE,Fitzpatrick E,Haas SA,Pope K,Hogan KJ,Gregg RG,Bromhead CJ,Wargowski DS,Lawrence CH,James PA,Churchyard A,Gao Y,Phelan DG,Gillies G,Salce N,Stanford L,Marsh AP,Mignogna ML,Hayflick SJ,Leventer RJ,Delatycki MB,Mellick GD,Kalscheuer VM,D'Adamo P,Bahlo M,Amor DJ,Lockhart PJ

Thu Dec 04 00:00:00 UTC 2014

Mutations in RAB39B cause X-linked intellectual disability and early-onset Parkinson disease with α-synuclein pathology.

American journal of human genetics

Thu Dec 04 00:00:00 UTC 2014

Identification and characterization of multiple novel Rab-myosin Va interactions.

Molecular biology of the cell

Lindsay AJ,Jollivet F,Horgan CP,Khan AR,Raposo G,McCaffrey MW,Goud B

Fri Nov 01 00:00:00 UTC 2013

Identification and characterization of multiple novel Rab-myosin Va interactions.

Molecular biology of the cell

Lindsay AJ,Jollivet F,Horgan CP,Khan AR,Raposo G,McCaffrey MW,Goud B

Fri Nov 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: Ras-related protein Rab-39B

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Gene Aliases: 6330580M05Rik; MRX72; RAB39B; WSMN

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UniProt ID: (Human) Q96DA2, (Mouse) Q8BHC1

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Entrez Gene ID: (Human) 116442, (Mouse) 67790

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Function(s)

protein binding GTP binding myosin V binding nucleotide binding GTPase activity

Process(es)

transport intracellular protein transport small GTPase mediated signal transduction protein transport vesicle-mediated transport Rab protein signal transduction synapse organization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RAB39B Polyclonal Antibody

RAB39B Antibody (12162-1-AP) in IHC (P)

Product Details

12162-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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