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RAB3A Polyclonal Antibody

RAB3A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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RAB3A Antibody (15029-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human gliomas tissue slide using (Product # 15029-1-AP) (RAB3A antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

RAB3A Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

15029-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RAB3A Fusion Protein Ag1903 (1-220 aa encoded by BC011782)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MASATDSRY GQKESSDQNF DYMFKILIIG NSSVGKTSFL FRYADDSFTP AFVSTVGIDF KVKTIYRNDK RIKLQIWDTA GQERYRTITT AYYRGAMGFI LMYDITNEES FNAVQDWSTQ IKTYSWDNAQ VLLVGNKCDM EDERVVSSER GRQLADHLGF EFFEASAKDN INVKQTFERL VDVICEKMSE SLDTADPAVT GAKQGPQLSD QQVPPHQDCA C (1-220 aa encoded by BC011782)

Target Information

Rab proteins belong to the Ras small GTPase superfamily. The GTP-binding Rab3 subfamily has 4 known isoforms: 3A, 3B, 3C, and 3D. These proteins are expressed in highest concentrations in brain and endocrine tissues and involved in regulated exocytosis of hormones and neurotransmitters. Specifically, Rab 3s are thought to play a key role in presynaptic vesicle trafficking and priming.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Overexpression of synaptic vesicle protein Rab GTPase 3C promotes vesicular exocytosis and drug resistance in colorectal cancer cells.

Molecular oncology

Chang YC,Li CH,Chan MH,Fang CY,Zhang ZX,Chen CL,Hsiao M

Wed Mar 01 00:00:00 UTC 2023

Overexpression of synaptic vesicle protein Rab GTPase 3C promotes vesicular exocytosis and drug resistance in colorectal cancer cells.

Molecular oncology

Chang YC,Li CH,Chan MH,Fang CY,Zhang ZX,Chen CL,Hsiao M

Wed Mar 01 00:00:00 UTC 2023

Overexpression of synaptic vesicle protein Rab GTPase 3C promotes vesicular exocytosis and drug resistance in colorectal cancer cells.

Molecular oncology

Chang YC,Li CH,Chan MH,Fang CY,Zhang ZX,Chen CL,Hsiao M

Wed Mar 01 00:00:00 UTC 2023

In situ cell-type-specific cell-surface proteomic profiling in mice.

Neuron

Shuster SA,Li J,Chon U,Sinantha-Hu MC,Luginbuhl DJ,Udeshi ND,Carey DK,Takeo YH,Xie Q,Xu C,Mani DR,Han S,Ting AY,Carr SA,Luo L

Wed Dec 07 00:00:00 UTC 2022

Zoledronate modulates intracellular vesicle trafficking in mast cells via disturbing the interaction of myosinVa/Rab3a and sytaxin4/VAMP7.

Biochemical pharmacology

Liu S,Sahid MNA,Takemasa E,Maeyama K,Mogi M

Tue May 01 00:00:00 UTC 2018

Zoledronate modulates intracellular vesicle trafficking in mast cells via disturbing the interaction of myosinVa/Rab3a and sytaxin4/VAMP7.

Biochemical pharmacology

Liu S,Sahid MNA,Takemasa E,Maeyama K,Mogi M

Tue May 01 00:00:00 UTC 2018

O-GlcNAcylation on Rab3A attenuates its effects on mitochondrial oxidative phosphorylation and metastasis in hepatocellular carcinoma.

Cell death & disease

Wu W,Zheng X,Wang J,Yang T,Dai W,Song S,Fang L,Wang Y,Gu J

Thu Sep 20 00:00:00 UTC 2018

O-GlcNAcylation on Rab3A attenuates its effects on mitochondrial oxidative phosphorylation and metastasis in hepatocellular carcinoma.

Cell death & disease

Wu W,Zheng X,Wang J,Yang T,Dai W,Song S,Fang L,Wang Y,Gu J

Thu Sep 20 00:00:00 UTC 2018

O-GlcNAcylation on Rab3A attenuates its effects on mitochondrial oxidative phosphorylation and metastasis in hepatocellular carcinoma.

Cell death & disease

Wu W,Zheng X,Wang J,Yang T,Dai W,Song S,Fang L,Wang Y,Gu J

Thu Sep 20 00:00:00 UTC 2018

O-GlcNAcylation on Rab3A attenuates its effects on mitochondrial oxidative phosphorylation and metastasis in hepatocellular carcinoma.

Cell death & disease

Wu W,Zheng X,Wang J,Yang T,Dai W,Song S,Fang L,Wang Y,Gu J

Thu Sep 20 00:00:00 UTC 2018

Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis.

Molecular cancer

Chang YC,Su CY,Chen MH,Chen WS,Chen CL,Hsiao M

Mon Aug 07 00:00:00 UTC 2017

Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis.

Molecular cancer

Chang YC,Su CY,Chen MH,Chen WS,Chen CL,Hsiao M

Mon Aug 07 00:00:00 UTC 2017

RanBP9 overexpression accelerates loss of pre and postsynaptic proteins in the APΔE9 transgenic mouse brain.

PloS one

Wang H,Wang R,Xu S,Lakshmana MK

Wed Sep 17 00:00:00 UTC 2014

RanBP9 overexpression accelerates loss of pre and postsynaptic proteins in the APΔE9 transgenic mouse brain.

PloS one

Wang H,Wang R,Xu S,Lakshmana MK

Wed Sep 17 00:00:00 UTC 2014

Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Lakshmana MK,Hayes CD,Bennett SP,Bianchi E,Reddy KM,Koo EH,Kang DE

Tue May 01 00:00:00 UTC 2012

Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Lakshmana MK,Hayes CD,Bennett SP,Bianchi E,Reddy KM,Koo EH,Kang DE

Tue May 01 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: C18A3.6; RAS-associated protein RAB3A; Ras-related protein Rab-3A; Ras-related small GTP binding protein 3A

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Gene Aliases: RAB3; RAB3A

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UniProt ID: (Human) P20336, (Rat) P63012, (Mouse) P63011

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Entrez Gene ID: (Human) 5864, (Rat) 25531, (Mouse) 19339

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Function(s)

ATPase activator activity GTPase activity protein binding GTP binding protein C-terminus binding myosin V binding GTPase binding ATPase binding GDP binding nucleotide binding

Process(es)

respiratory system process intracellular protein transport vesicle docking involved in exocytosis mitochondrion organization neuromuscular synaptic transmission axonogenesis metabolic process protein secretion post-embryonic development synaptic vesicle exocytosis synaptic vesicle maturation regulation of exocytosis lung development regulation of synaptic vesicle fusion to presynaptic membrane Rab protein signal transduction positive regulation of ATPase activity synaptic vesicle recycling regulation of short-term neuronal synaptic plasticity maintenance of presynaptic active zone structure sensory perception of touch response to electrical stimulus protein localization to plasma membrane positive regulation of regulated secretory pathway transport exocytosis small GTPase mediated signal transduction protein transport synaptic vesicle transport evoked neurotransmitter secretion regulation of long-term synaptic potentiation neurotransmitter secretion glutamate secretion constitutive secretory pathway positive regulation of exocytosis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RAB3A Polyclonal Antibody

RAB3A Antibody (15029-1-AP) in IHC (P)

Product Details

15029-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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