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Proteintech
RAB3GAP1 Monoclonal Antibody (4A3A1), CoraLite® Plus 488
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Product Details
CL48866688100UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4A3A1
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Wet ice
Target Information
RAB3GAP1, is a 981 amino acid protein that belongs to the Rab3-GAP catalytic subunit family. Rab 3 GAP p130 converts active RAB3-GTP to the inactive form RAB3-GDP, and is required for normal eye and brain development. Defects in Rab 3 GAP p130 are the cause of Warburg micro syndrome 1 (WARBM1). WARBM1 is a severe autosomal recessive disorder characterized by developmental abnormalities of the eye and central nervous system and by microgenitalia. The Rab 3 GAP p130 protein may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Rab 3 GAP p130; Rab3 GAP p130; RAB3 GTPase activating protein subunit 1 (catalytic); RAB3 GTPase-activating protein 130 kDa subunit; Rab3 GTPase-activating protein catalytic subunit; Rab3-GAP; Rab3-GAP p130
Gene Aliases: 1700003B17Rik; 4732493F09Rik; AL117896; KIAA0066; P130; RAB3GAP; RAB3GAP1; RAB3GAP130; WARBM1
UniProt ID: (Human) Q15042, (Mouse) Q80UJ7
Entrez Gene ID: (Human) 22930, (Mouse) 226407
brain development
positive regulation of gene expression
regulation of synaptic vesicle priming
hypothalamus development
lipid particle organization
camera-type eye development
regulation of GTPase activity
positive regulation of GTPase activity
regulation of short-term neuronal synaptic plasticity
synaptic vesicle transport
protein stabilization
excitatory postsynaptic potential
face morphogenesis
positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization
establishment of protein localization to endoplasmic reticulum membrane
regulation of calcium ion-dependent exocytosis of neurotransmitter
positive regulation of endoplasmic reticulum tubular network organization
positive regulation of protein lipidation
positive regulation of autophagosome assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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