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Invitrogen
RAB3IP Polyclonal Antibody
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FIGURE: 1 / 3
RAB3IP Antibody (PA5-96927) in WB
Western blot analysis of RAB3IP in extracts of various cell lines. Samples were incubated with RAB3IP Polyclonal antibody (Product # PA5-96927) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Product Details
PA5-96927
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human RAB3IP (NP_0719012)
Conjugate
Form
Liquid
Concentration
0.73 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2808729
Product Specific Information
Immunogen sequence: MANDPLEGFH EVNLASPTSP DLLGVYESGT QEQTTSPSVI YRPHPSALSS VPIQANALDV SELPTQPVYS SPRRLNCAEI SSISFHVTDP APCSTSGVTA GLTKLTTRKD NYNAEREFLQ GATITEACDG SDDIFGLSTD SLSRLRSPSV; Positive Samples: HeLa, A-549, 293T, Mouse heart, Mouse kidney, Mouse brain, Mouse liver, Rat brain, Rat testis; Cellular Location: Cell projection, Cytoplasm, Nucleus, cytoskeleton, lamellipodium
Target Information
Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: gene trap PAT 12; Rab-3A-interacting protein; RAB3A-interacting protein; RAB3IP; rab3ip {ECO:0000250|UniProtKB:Q96QF0}; rabin 3; Rabin-3; Rabin8; SSX2 interacting protein; SSX2-interacting protein
Gene Aliases: B230311A06; Gtpat12; RAB3IP; RABIN3; RABIN8
UniProt ID: (Human) Q96QF0, (Rat) Q62739, (Mouse) Q68EF0
Entrez Gene ID: (Human) 117177, (Rat) 29885, (Mouse) 216363
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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