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Proteintech
RAB5A Monoclonal Antibody (1B6A5), CoraLite® 594
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Product Details
CL594-66339
Product Specifications
Species Reactivity
Human,
Pig
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1B6A5
Immunogen
Full length RAB5 protein.
Conjugate
Excitation/Emission Max
593/614 nm
Form
Liquid
Concentration
2 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Target Information
RAB5 are among the small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Rab 5; Rab 5A; Ras related protein; RAS-associated protein RAB5A; Ras-related protein Rab-5A
Gene Aliases: RAB5; RAB5A
UniProt ID: (Human) P20339, (Pig) Q06AU6
Entrez Gene ID: (Human) 5868, (Pig) 100144499
endocytosis
phagocytosis
small GTPase mediated signal transduction
blood coagulation
protein transport
regulation of endocytosis
synaptic vesicle recycling
early endosome to late endosome transport
positive regulation of exocytosis
regulation of endosome size
regulation of filopodium assembly
receptor internalization involved in canonical Wnt signaling pathway
regulation of synaptic vesicle exocytosis
regulation of autophagosome assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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