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Osenses
RAB6A/RAB6C Polyclonal Antibody
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RAB6A/RAB6C Antibody (OSR00344W-100UL) in IHC (P)
IHC-P on paraffin sections of rat kidney. The animal was perfused using Autoperfuser at a pressure of 110 mmHg with 300 mL 4% FA and further post fixed overnight before being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions.... View More
Product Details
OSR00344W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from c-terminal region of human Ras-related protein Rab-6A (RAB6A) conjugated to an immunogenic carrier protein has been used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The antigen shares 85% identity with RAB6C.
Specificity of this antibody: RAB6A and RAB6C.
Target Information
GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Rab GTPase; Rab-6; RAB6, member RAS oncogene family; Rab6-like protein WTH3; RAB6B, member RAS oncogene family; Ras-related protein Rab-6A; Ras-related protein Rab-6B; Ras-related protein Rab-6C; small GTP-binding protein; small GTPase RAB6B
Gene Aliases: 2610028L11Rik; 9630015C03; AA419671; AI844641; C330006L04Rik; D9Bwg0185e; MNCb-1660; RAB6; RAB6A; RAB6B; RAB6C; RCO4-3; WTH3
UniProt ID: (Human) P20340, (Human) Q9NRW1, (Human) Q9H0N0, (Mouse) P35279, (Mouse) P61294
Entrez Gene ID: (Human) 5870, (Human) 51560, (Human) 84084, (Rat) 84379, (Mouse) 19346, (Mouse) 270192, (Rat) 363123
protein targeting to Golgi
retrograde vesicle-mediated transport, Golgi to ER
small GTPase mediated signal transduction
viral process
peptidyl-cysteine methylation
antigen processing and presentation
protein localization to Golgi apparatus
early endosome to Golgi transport
minus-end-directed organelle transport along microtubule
intra-Golgi vesicle-mediated transport
protein transport
retrograde transport, endosome to Golgi
intracellular protein transport
metabolic process
Rab protein signal transduction
positive regulation of ATPase activity
Golgi vesicle transport
transport
vesicle-mediated transport
regulation of centrosome duplication
cell cycle process
response to drug
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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