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Abnova
RAB7L1 Monoclonal Antibody (1B10)
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Product Details
H00008934-M02
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
1B10
Immunogen
RAB7L1 (AAH02585, 1 a.a. approximately 203 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: MGSRDHLFKV LVVGDAAVGK TSLVQRYSQD SFSKHYKSTV GVDFALKVLQ WSDYEIVRLQ LWDIAGQERF TSMTRLYYRD ASACVIMFDV TNATTFSNSQ RWKQDLDSKL TLPNGEPVPC LLLANKCDLS PWAVSRDQID RFSKENGFTG WTETSVKENK NINEAMRVLI EKMMRNSTED IMSLSTQGDY INLQTKSSSW SCC
Target Information
Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection. {ECO:0000269; PubMed:22042847, ECO:0000269; PubMed:24788816}.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Rab-7-like protein 1; RAB7, member RAS oncogene family-like 1; Ras-related protein Rab-29; Ras-related protein Rab-7L1
Gene Aliases: RAB29; RAB7L; RAB7L1
UniProt ID: (Human) O14966
Entrez Gene ID: (Human) 8934
ER to Golgi vesicle-mediated transport
Golgi to endosome transport
Golgi organization
small GTPase mediated signal transduction
response to bacterium
negative regulation of neuron projection development
symbiont intracellular protein transport in host
melanosome organization
retrograde transport, plasma membrane to Golgi
retrograde transport, endosome to Golgi
protein localization to membrane
positive regulation of intracellular protein transport
regulation of neuron death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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