Invitrogen

RAC1/RAC2/RAC3 Recombinant Rabbit Monoclonal Antibody (2J4S6)

View all (5) RAC1/RAC2/RAC3 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-35636

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

2J4S6

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-189 of human RAC1(P63000)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.6 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849536

Product Specific Information

Immunogen sequence: MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE VRHHCPNTPI ILVGTKLDLR DDKDTIEKLK EKKLTPITYP QGLAMAKEIG AVKYLECSAL TQRGLKTVFD EAIRAVLCPP PVKKRKRKC

Target Information

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cell migration-inducing gene 5 protein; EN-7 protein; GX; p21-Rac1; p21-Rac2; p21-Rac3; Protein EN-7; Ras-like protein TC25; RAS-related C3 botulinum substrate 2; Ras-related C3 botulinum toxin substrate 1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1); Ras-related C3 botulinum toxin substrate 2; Ras-related C3 botulinum toxin substrate 3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3); Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2); rho family, small GTP binding protein Rac1; rho family, small GTP binding protein Rac3; Small G protein

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Gene Aliases: AI323801; AI452260; AL023026; D5Ertd559e; EN-7; Gx; HSPC022; MIG5; p21-Rac1; p21-Rac2; Rac; Rac-1; RAC1; Rac1B; RAC2; RAC3; TC-25; TC25

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UniProt ID: (Human) P63000, (Human) P15153, (Human) P60763, (Mouse) P63001, (Rat) Q6RUV5, (Mouse) Q05144, (Mouse) P60764

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Entrez Gene ID: (Human) 5879, (Human) 5880, (Human) 5881, (Mouse) 19353, (Rat) 363875, (Rat) 366957, (Mouse) 19354, (Mouse) 170758, (Rat) 688319

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Function(s)
GTPase activity protein binding GTP binding Rab GTPase binding enzyme binding protein kinase binding GTP-dependent protein binding thioesterase binding histone deacetylase binding Rho GDP-dissociation inhibitor binding protein kinase regulator activity calcium-dependent protein binding nucleotide binding
Process(es)
small GTPase mediated signal transduction metabolic process regulation of neuron maturation cerebral cortex GABAergic interneuron development regulation of cell morphogenesis cell projection assembly actin cytoskeleton organization neuron projection development positive regulation of cell adhesion mediated by integrin homeostasis of number of cells within a tissue neuromuscular process controlling balance neuromuscular process synaptic transmission, GABAergic positive regulation of substrate adhesion-dependent cell spreading chemotaxis actin filament organization G-protein coupled receptor signaling pathway positive regulation of cell proliferation positive regulation of lamellipodium assembly regulation of cell-substrate adhesion bone resorption regulation of respiratory burst lymphocyte aggregation positive regulation of neutrophil chemotaxis regulation of neutrophil migration positive regulation of protein phosphorylation auditory receptor cell morphogenesis mast cell chemotaxis epithelial cell morphogenesis endocytosis phagocytosis, engulfment hyperosmotic response cytoskeleton organization cell adhesion axon guidance cell proliferation regulation of fibroblast migration positive regulation of cell-substrate adhesion dendrite development cell migration cerebral cortex radially oriented cell migration embryonic olfactory bulb interneuron precursor migration lamellipodium assembly actin filament polymerization regulation of cell migration positive regulation of actin filament polymerization ruffle organization negative regulation of interleukin-23 production substrate adhesion-dependent cell spreading positive regulation of phosphatidylinositol 3-kinase activity engulfment of apoptotic cell cell-cell junction organization positive regulation of DNA replication anatomical structure arrangement dendrite morphogenesis cell motility positive regulation of stress fiber assembly localization within membrane positive regulation of focal adhesion assembly Wnt signaling pathway, planar cell polarity pathway cellular response to mechanical stimulus semaphorin-plexin signaling pathway dopaminergic neuron differentiation protein localization to plasma membrane cochlea morphogenesis ruffle assembly positive regulation of protein targeting to mitochondrion intracellular signal transduction regulation of small GTPase mediated signal transduction signal transduction regulation of hydrogen peroxide metabolic process platelet activation regulation of T cell proliferation regulation of mast cell degranulation regulation of protein kinase activity regulation of mast cell chemotaxis movement of cell or subcellular component inflammatory response cell-matrix adhesion blood coagulation regulation of cell size response to wounding anatomical structure morphogenesis T cell costimulation positive regulation of Rho protein signal transduction Fc-epsilon receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis positive regulation of apoptotic process vascular endothelial growth factor receptor signaling pathway ephrin receptor signaling pathway negative regulation of receptor-mediated endocytosis regulation of defense response to virus by virus Rac protein signal transduction
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