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Invitrogen
RAD50 Monoclonal Antibody (3D2G10)
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Product Details
MA5-38619
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
3D2G10
Immunogen
Purified recombinant fragment of human RAD50 (aa: 228-359) expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2898531
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
Rad50-13B3 recognizes human Rad50, a 153a protein involved in DNA double strand break repair. Rad50 is associated with Mre11 and p95 (Nibrin) to form a multiprotein complex involved in the double strand break repair process. Upon DNA damage, Rad50 and Mre11 redistribute and are co-localized within the nucleus of damaged cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA repair protein RAD50; hRAD50; hsRAD50; RAD50 2; RAD50 homolog, double strand break repair protein; RAD50 PEN; RAD50-2; RAD50-3
Gene Aliases: hRad50; NBSLD; RAD50; RAD502
UniProt ID: (Human) Q92878, (Rat) Q9JIL8
Entrez Gene ID: (Human) 10111, (Rat) 64012
single-stranded DNA endodeoxyribonuclease activity
DNA binding
double-stranded telomeric DNA binding
ATP-dependent DNA helicase activity
adenylate kinase activity
protein binding
ATP binding
3'-5' exonuclease activity
protein binding, bridging
single-stranded telomeric DNA binding
metal ion binding
G-quadruplex DNA binding
ATPase activity
regulation of mitotic recombination
telomere maintenance
DNA catabolic process, endonucleolytic
DNA repair
double-strand break repair
DNA recombination
cellular response to DNA damage stimulus
telomere maintenance via telomerase
reciprocal meiotic recombination
regulation of mitotic cell cycle
positive regulation of protein autophosphorylation
DNA duplex unwinding
positive regulation of kinase activity
negative regulation of viral entry into host cell
chromosome organization
protein heterooligomerization
chromosome organization involved in meiotic cell cycle
nucleic acid phosphodiester bond hydrolysis
telomere maintenance via recombination
double-strand break repair via homologous recombination
DNA double-strand break processing
DNA synthesis involved in DNA repair
strand displacement
DNA replication
double-strand break repair via nonhomologous end joining
viral process
telomeric 3' overhang formation
positive regulation of telomere maintenance
nucleotide phosphorylation
regulation of signal transduction by p53 class mediator
negative regulation of telomere capping
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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