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Invitrogen
RAD51 Recombinant Rabbit Monoclonal Antibody (23GB4600)
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FIGURE: 1 / 4
RAD51 Antibody (MA5-53778) in ICC/IF
Immunocytochemistry analysis of RAD51 in HAP-1 cells. Nuclei were stained blue with DAPI; RAD51 recombinant monoclonal antibody (Product # MA5-53778) with a dilution of 1:1,000 was stained magenta with Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
Product Details
MA5-53778
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB4600
Immunogen
A synthesized peptide derived from human Rad51 (1-84AA).
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3248249
Target Information
RAD51 plays a critical role in homologous strand exchange, a key step in DNA repair through homologous recobination. It binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. RAD51 catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. It binds to a single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Mutations in the gene can results in breast cancer, mirror movements 2 and fanconi anemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BRCA1/BRCA2-containing complex, subunit 5; DNA repair protein RAD51 homolog 1; HsRAD51; RAD51 homolog; RAD51 homolog A; RecA, E. coli, homolog of; RecA-like protein; recombination protein A
Gene Aliases: AV304093; BRCC5; FANCR; HRAD51; HsRad51; HsT16930; MRMV2; RAD51; RAD51A; RECA; RGD1563603
UniProt ID: (Human) Q06609, (Mouse) Q08297
Entrez Gene ID: (Human) 5888, (Mouse) 19361, (Rat) 499870
recombinase activity
four-way junction DNA binding
chromatin binding
double-stranded DNA binding
single-stranded DNA binding
endodeoxyribonuclease activity
protein binding
ATP binding
protein C-terminus binding
identical protein binding
single-stranded DNA-dependent ATPase activity
DNA polymerase binding
nucleotide binding
DNA binding
damaged DNA binding
DNA-dependent ATPase activity
molecular_function
double-strand break repair via homologous recombination
regulation of protein phosphorylation
DNA metabolic process
DNA unwinding involved in DNA replication
DNA repair
DNA recombination
cellular response to DNA damage stimulus
meiotic nuclear division
reciprocal meiotic recombination
regulation of double-strand break repair via homologous recombination
replication fork processing
telomere organization
positive regulation of DNA ligation
protein homooligomerization
chromosome organization involved in meiotic cell cycle
cellular response to alkaloid
cellular response to ionizing radiation
cellular response to hydroxyurea
cellular response to camptothecin
replication-born double-strand break repair via sister chromatid exchange
telomere maintenance via recombination
DNA recombinase assembly
DNA synthesis involved in DNA repair
strand displacement
mitotic recombination
response to toxic substance
response to X-ray
telomere maintenance via telomere lengthening
strand invasion
response to drug
cellular response to gamma radiation
cellular response to cisplatin
response to etoposide
mitotic recombination-dependent replication fork processing
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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