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Proteintech
RAF1 Monoclonal Antibody (1D6A1)
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Product Details
66592-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1D6A1
Immunogen
RAF1 Fusion Protein Ag25423 (1-59 aa encoded by BC018119)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MEHIQGAWK TISNGFGFKD AVFDGSSCIS PTIVQQFGYQ RRASDDGKLT DPSKTSNTIR (1-59 aa encoded by BC018119 )
Target Information
Raf-1 (c-Raf) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C-Raf proto-oncogene, serine/threonine kinase; cRaf; Craf1 transforming; EC 2.7.11.1; kinase Raf1; murine sarcoma 3611 oncogene 1; Oncogene RAF1; OTTHUMP00000207813; OTTHUMP00000209389; Proto-oncogene c-RAF; raf proto-oncogene serine/threonine protein kinase; RAF proto-oncogene serine/threonine-protein kinase; Raf-1; sarcoma 3611 oncogene; v-raf-1 leukemia viral oncogene 1; v-raf-1 murine leukemia viral oncogene homolog 1; v-raf-1 murine leukemia viral oncogene-like protein 1; vraf1 murine le
Gene Aliases: 6430402F14Rik; AA990557; BB129353; c-Raf; CMD1NN; CRAF; Craf1; D830050J10Rik; NS5; RAF; Raf-1; RAF1; v-Raf
UniProt ID: (Human) P04049, (Mouse) Q99N57
Entrez Gene ID: (Human) 5894, (Mouse) 110157
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase kinase activity
protein binding
ATP binding
kinase activity
small GTPase binding
mitogen-activated protein kinase kinase binding
identical protein binding
metal ion binding
protein heterodimerization activity
nucleotide binding
receptor signaling protein activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Ras GTPase binding
MAPK cascade
activation of MAPKK activity
response to hypoxia
cellular glucose homeostasis
positive regulation of protein phosphorylation
protein phosphorylation
signal transduction
negative regulation of cell proliferation
phosphorylation
cell differentiation
negative regulation of protein complex assembly
positive regulation of peptidyl-serine phosphorylation
somatic stem cell population maintenance
intracellular signal transduction
insulin secretion involved in cellular response to glucose stimulus
response to muscle stretch
negative regulation of apoptotic process
intermediate filament cytoskeleton organization
positive regulation of transcription from RNA polymerase II promoter
neurotrophin TRK receptor signaling pathway
death-inducing signaling complex assembly
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
stimulatory C-type lectin receptor signaling pathway
apoptotic process
activation of adenylate cyclase activity
heart development
cell proliferation
platelet activation
thyroid gland development
ion transmembrane transport
regulation of Rho protein signal transduction
wound healing
regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cell differentiation
thymus development
face development
regulation of cell motility
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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