Proteintech

RAIDD Polyclonal Antibody

RAIDD Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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RAIDD Antibody (10401-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human colon cancer using 10401-1-AP (RAIDD antibody) at dilution of 1:100 (under 25x lens).

RAIDD Antibody in Immunoprecipitation (IP)

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Product Details

10401-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RAIDD Fusion Protein Ag0630 (1-199 aa encoded by BC017042)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MEARDKQVL RSLRLELGAE VLVEGLVLQY LYQEGILTEN HIQEINAQTT GLRKTMLLLD ILPSRGPKAF DTFLDSLQEF PWVREKLKKA REEAMTDLPA GDRLTGIPSH ILNSSPSDRQ INQLAQRLGP EWEPMVLSLG LSQTDIYRCK ANHPHNVQSQ VVEAFIRWRQ RFGKQATFQS LHNGLRAVEV DPSLLLHMLE (1-199 aa encoded by BC017042)

Target Information

The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis.

Cell metabolism

Kim JY,Wang LQ,Sladky VC,Oh TG,Liu J,Trinh K,Eichin F,Downes M,Hosseini M,Jacotot ED,Evans RM,Villunger A,Karin M

Tue Oct 04 00:00:00 UTC 2022

E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration.

Developmental cell

Sladky VC,Knapp K,Soratroi C,Heppke J,Eichin F,Rocamora-Reverte L,Szabo TG,Bongiovanni L,Westendorp B,Moreno E,van Liere EA,Bakker B,Spierings DCJ,Wardenaar R,Pereyra D,Starlinger P,Schultze S,Trauner M,Stojakovic T,Scharnagl H,Fava LL,Foijer F,de Bruin A,Villunger A

Mon Feb 10 00:00:00 UTC 2020

PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis.

EMBO reports

Sladky VC,Knapp K,Szabo TG,Braun VZ,Bongiovanni L,van den Bos H,Spierings DC,Westendorp B,Curinha A,Stojakovic T,Scharnagl H,Timelthaler G,Tsuchia K,Pinter M,Semmler G,Foijer F,de Bruin A,Reiberger T,Rohr-Udilova N,Villunger A

Thu Dec 03 00:00:00 UTC 2020

The adaptor CRADD/RAIDD controls activation of endothelial cells by proinflammatory stimuli.

The Journal of biological chemistry

Qiao H,Liu Y,Veach RA,Wylezinski L,Hawiger J

Fri Aug 08 00:00:00 UTC 2014

The adaptor CRADD/RAIDD controls activation of endothelial cells by proinflammatory stimuli.

The Journal of biological chemistry

Qiao H,Liu Y,Veach RA,Wylezinski L,Hawiger J

Fri Aug 08 00:00:00 UTC 2014

The adaptor CRADD/RAIDD controls activation of endothelial cells by proinflammatory stimuli.

The Journal of biological chemistry

Qiao H,Liu Y,Veach RA,Wylezinski L,Hawiger J

Fri Aug 08 00:00:00 UTC 2014

Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes.

Journal of immunology (Baltimore, Md. : 1950)

Lin Q,Liu Y,Moore DJ,Elizer SK,Veach RA,Hawiger J,Ruley HE

Thu Mar 15 00:00:00 UTC 2012

Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes.

Journal of immunology (Baltimore, Md. : 1950)

Lin Q,Liu Y,Moore DJ,Elizer SK,Veach RA,Hawiger J,Ruley HE

Thu Mar 15 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: CASP2 and RIPK1 domain-containing adaptor with death domain; Caspase and RIP adapter with death domain; caspase and RIP adaptor with death domain; death adaptor molecule RAIDD; death domain containing protein CRADD; Death domain-containing protein CRADD; MGC9163; RIP-associated ICH1/CED3-homologous protein with death domain; RIP-associated protein with a death domain

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Gene Aliases: CRADD; MRT34; RAIDD

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UniProt ID: (Human) P78560, (Mouse) O88843

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Entrez Gene ID: (Human) 8738, (Rat) 314756, (Mouse) 12905

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Function(s)

protease binding protein binding protein binding, bridging death domain binding

Process(es)

activation of cysteine-type endopeptidase activity involved in apoptotic process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest cellular response to mechanical stimulus positive regulation of apoptotic signaling pathway apoptotic process signal transduction regulation of apoptotic process extrinsic apoptotic signaling pathway via death domain receptors

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RAIDD Polyclonal Antibody

RAIDD Antibody (10401-1-AP) in IHC (P)

Product Details

10401-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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