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Product Details
MA5-38173
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
3Z9N8
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 100-199 of human RAIDD/CRADD (NP_0037961)
Conjugate
Form
Liquid
Concentration
0.65 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2898090
Product Specific Information
Positive Samples: HT-29, 293T, K-562
Immunogen sequence: GDRLTGIPSH ILNSSPSDRQ INQLAQRLGP EWEPMVLSLG LSQTDIYRCK ANHPHNVQSQ VVEAFIRWRQ RFGKQATFQS LHNGLRAVEV DPSLLLHMLE
Target Information
The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Caspase and RIP adapter with death domain; caspase and RIP adaptor with death domain; death adaptor molecule RAIDD; death domain containing protein CRADD; Death domain-containing protein CRADD; MGC9163; RIP-associated ICH1/CED3-homologous protein with death domain; RIP-associated protein with a death domain
Gene Aliases: CRADD; MRT34; RAIDD
UniProt ID: (Human) P78560
Entrez Gene ID: (Human) 8738, (Rat) 314756
activation of cysteine-type endopeptidase activity involved in apoptotic process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
cellular response to mechanical stimulus
positive regulation of apoptotic signaling pathway
extrinsic apoptotic signaling pathway via death domain receptors
regulation of apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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