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Product Details
MA5-27490
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
OTI8E1
Immunogen
Full length human recombinant protein of RANBP1 produced in HEK293T cell
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2725189
Target Information
Ran/TC4-binding protein, RanBP1, interacts specifically with GTP-charged RAN. RANBP1 encodes a 23-kD protein that binds to RAN complexed with GTP but not GDP. RANBP1 does not activate GTPase activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase-activating protein (RanGAP1). The RANBP1 cDNA encodes a 201-amino acid protein that is 92% similar to its mouse homolog. In both mammalian cells and in yeast, RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HpaII tiny fragments locus 9A; Ran-binding protein 1; Ran-specific GTPase-activating protein; RanBP1; RANG; testis secretory sperm-binding protein Li 221n
Gene Aliases: HTF9A; RANBP1
UniProt ID: (Human) P43487
Entrez Gene ID: (Human) 5902
G1/S transition of mitotic cell cycle
RNA export from nucleus
ubiquitin-dependent protein catabolic process
protein import into nucleus
spindle organization
signal transduction
viral process
positive regulation of GTPase activity
positive regulation of mitotic centrosome separation
cell-cell adhesion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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