Proteintech

RAP1B Polyclonal Antibody

RAP1B Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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RAP1B Antibody (10840-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human esophagus cancer tissue slide using (Product # 10840-1-AP) (RAP1B antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

10840-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 10 publications 10 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunoprecipitation (IP)

View 1 publication 1 publication

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RAP1B Fusion Protein Ag1282 (1-184 aa encoded by BC000176)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MREYKLVVL GSGGVGKSAL TVQFVQGIFV EKYDPTIEDS YRKQVEVDAQ QCMLEILDTA GTEQFTAMRD LYMKNGQGFA LVYSITAQST FNDLQDLREQ ILRVKDTDDV PMILVGNKCD LEDERVVGKE QGQNLARQWN NCAFLESSAK SKINVNEIFY DLVRQINRKT PVPGKARKKS SCQLL (1-184 aa encoded by BC000176)

Target Information

Ran (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 (RCC1).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Roles of the hsa_circ_0013880/USP32/Rap1b axis in the proliferation and apoptosis of acute myeloid leukemia cells.

Acta biochimica et biophysica Sinica

Zhang H,Tao Y,Ding X,Wang Y,Wang X

Sat Mar 25 00:00:00 UTC 2023

SNORA70E promotes the occurrence and development of ovarian cancer through pseudouridylation modification of RAP1B and alternative splicing of PARPBP.

Journal of cellular and molecular medicine

Chen S,Li QH,Chen X,Bao HJ,Wu W,Shen F,Lu BF,Jiang RQ,Zong ZH,Zhao Y

Sat Oct 01 00:00:00 UTC 2022

Avian Hepatitis E Virus ORF2 Protein Interacts with Rap1b to Induce Cytoskeleton Rearrangement That Facilitates Virus Internalization.

Microbiology spectrum

Zhang B,Fan M,Fan J,Luo Y,Wang J,Wang Y,Liu B,Sun Y,Zhao Q,Hiscox JA,Nan Y,Zhou EM

Wed Feb 23 00:00:00 UTC 2022

Avian Hepatitis E Virus ORF2 Protein Interacts with Rap1b to Induce Cytoskeleton Rearrangement That Facilitates Virus Internalization.

Microbiology spectrum

Zhang B,Fan M,Fan J,Luo Y,Wang J,Wang Y,Liu B,Sun Y,Zhao Q,Hiscox JA,Nan Y,Zhou EM

Wed Feb 23 00:00:00 UTC 2022

33-kDa ANXA3 isoform contributes to hepatocarcinogenesis via modulating ERK, PI3K/Akt-HIF and intrinsic apoptosis pathways.

Journal of advanced research

Guo C,Li N,Dong C,Wang L,Li Z,Liu Q,Ma Q,Greenaway FT,Tian Y,Hao L,Liu S,Sun MZ

Sat May 01 00:00:00 UTC 2021

Molecular and Pharmacological Characterization of the Interaction between Human Geranylgeranyltransferase Type I and Ras-Related Protein Rap1B.

International journal of molecular sciences

Hinz S,Jung D,Hauert D,Bachmann HS

Tue Mar 02 00:00:00 UTC 2021

Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis.

Molecular cell

Zhang Y,Yu G,Chu H,Wang X,Xiong L,Cai G,Liu R,Gao H,Tao B,Li W,Li G,Liang J,Yang W

Thu Jul 19 00:00:00 UTC 2018

Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis.

Molecular cell

Zhang Y,Yu G,Chu H,Wang X,Xiong L,Cai G,Liu R,Gao H,Tao B,Li W,Li G,Liang J,Yang W

Thu Jul 19 00:00:00 UTC 2018

LncRNA AFAP1-AS Functions as a Competing Endogenous RNA to Regulate RAP1B Expression by sponging miR-181a in the HSCR.

International journal of medical sciences

Chen G,Peng L,Zhu Z,Du C,Shen Z,Zang R,Su Y,Xia Y,Tang W

Mon May 21 00:00:00 UTC 2018

LncRNA AFAP1-AS Functions as a Competing Endogenous RNA to Regulate RAP1B Expression by sponging miR-181a in the HSCR.

International journal of medical sciences

Chen G,Peng L,Zhu Z,Du C,Shen Z,Zang R,Su Y,Xia Y,Tang W

Mon May 21 00:00:00 UTC 2018

LncRNA MT1JP functions as a tumor suppressor by interacting with TIAR to modulate the p53 pathway.

Oncotarget

Liu L,Yue H,Liu Q,Yuan J,Li J,Wei G,Chen X,Lu Y,Guo M,Luo J,Chen R

Tue Mar 29 00:00:00 UTC 2016

LncRNA MT1JP functions as a tumor suppressor by interacting with TIAR to modulate the p53 pathway.

Oncotarget

Liu L,Yue H,Liu Q,Yuan J,Li J,Wei G,Chen X,Lu Y,Guo M,Luo J,Chen R

Tue Mar 29 00:00:00 UTC 2016

MicroRNA-100 regulates SW620 colorectal cancer cell proliferation and invasion by targeting RAP1B.

Oncology reports

Peng H,Luo J,Hao H,Hu J,Xie SK,Ren D,Rao B

Thu May 01 00:00:00 UTC 2014

Functional analysis of miR-101-3p and Rap1b involved in hepatitis B virus-related hepatocellular carcinoma pathogenesis.

Biochemistry and cell biology = Biochimie et biologie cellulaire

Sheng Y,Ding S,Chen K,Chen J,Wang S,Zou C,Zhang J,Cao Y,Huang A,Tang H

Tue Apr 01 00:00:00 UTC 2014

Functional analysis of miR-101-3p and Rap1b involved in hepatitis B virus-related hepatocellular carcinoma pathogenesis.

Biochemistry and cell biology = Biochimie et biologie cellulaire

Sheng Y,Ding S,Chen K,Chen J,Wang S,Zou C,Zhang J,Cao Y,Huang A,Tang H

Tue Apr 01 00:00:00 UTC 2014

Regulation of RAP1B by miR-139 suppresses human colorectal carcinoma cell proliferation.

The international journal of biochemistry & cell biology

Guo H,Hu X,Ge S,Qian G,Zhang J

Sat Sep 01 00:00:00 UTC 2012

Regulation of RAP1B by miR-139 suppresses human colorectal carcinoma cell proliferation.

The international journal of biochemistry & cell biology

Guo H,Hu X,Ge S,Qian G,Zhang J

Sat Sep 01 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: GTP-binding protein smg p21B; Ras family small GTP binding protein RAP1B; RAS related protein 1b; Ras-related protein Rap-1b; RAS-related protein RAP1B; small GTP binding protein

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Gene Aliases: 2810443E11Rik; K-REV; OK/SW-cl.11; RAL1B; RAP1B

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UniProt ID: (Human) P61224, (Rat) Q62636, (Mouse) Q99JI6

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Entrez Gene ID: (Human) 5908, (Rat) 171337, (Mouse) 215449

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Function(s)

GTPase activity protein binding GTP binding GDP binding protein complex binding nucleotide binding

Process(es)

small GTPase mediated signal transduction metabolic process cell proliferation microvillus assembly Rap protein signal transduction negative regulation of calcium ion-dependent exocytosis establishment of endothelial barrier positive regulation of ERK1 and ERK2 cascade cellular response to cAMP regulation of cell junction assembly regulation of establishment of cell polarity negative regulation of synaptic vesicle exocytosis signal transduction

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RAP1B Polyclonal Antibody

RAP1B Antibody (10840-1-AP) in IHC (P)

Product Details

10840-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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