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Invitrogen
RAP1B Polyclonal Antibody
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Product Details
PA5-88865
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-184 of human Rap1B (NP_0564611)
Conjugate
Form
Liquid
Concentration
1.33 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2805181
Product Specific Information
Immunogen sequence: MREYKLVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY RKQVEVDAQQ CMLEILDTAG TEQFTAMRDL YMKNGQGFAL VYSITAQSTF NDLQDLREQI LRVKDTDDVP MILVGNKCDL EDERVVGKEQ GQNLARQWNN CAFLESSAKS KINVNEIFYD LVRQINRKTP VPGKARKKSS CQLL; Positive Samples: A-549, HeLa, Mouse kidney; Cellular Location: Cell junction, Cell membrane, Cytoplasm, cytosol
Target Information
Ran (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 (RCC1).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GTP-binding protein smg p21B; Ras family small GTP binding protein RAP1B; Ras-related protein Rap-1b; RAS-related protein RAP1B; small GTP binding protein
Gene Aliases: 2810443E11Rik; K-REV; OK/SW-cl.11; RAL1B; RAP1B
UniProt ID: (Human) P61224, (Mouse) Q99JI6
Entrez Gene ID: (Human) 5908, (Mouse) 215449
signal transduction
small GTPase mediated signal transduction
metabolic process
cell proliferation
Rap protein signal transduction
negative regulation of calcium ion-dependent exocytosis
establishment of endothelial barrier
positive regulation of ERK1 and ERK2 cascade
cellular response to cAMP
regulation of cell junction assembly
regulation of establishment of cell polarity
negative regulation of synaptic vesicle exocytosis
microvillus assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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