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Invitrogen
RAP2A Polyclonal Antibody
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RAP2A Antibody (PA5-23298) in WB
Western blot analysis of RAP2A in MCF7 cell lysate in the 1) absence and 2) presence of immunizing peptide. Samples were incubated in RAP2A polyclonal antibody (Product # PA5-23298) using a dilution of 0.1 µg/mL followed by a goat anti-rabbit Ig HRP secondary antibody. PicoTect ECL substrate solution was used for this test.
Product Details
PA5-23298
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Chicken,
Horse,
Human,
Marsupial,
Mouse,
Non-human primate,
Xenopus
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A portion of amino acids 140-183 of human RAP2A
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2540822
Target Information
RAP2A is a small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: RAP2, member of RAS oncogene family (K-rev); RAP2A, member of RAS oncogene family; Ras-related protein Rap-2a; RbBP-30; RP11-128N14.2
Gene Aliases: 5830461H18Rik; K-REV; KREV; RAP2; RAP2A; RbBP-30
UniProt ID: (Human) P10114, (Mouse) Q80ZJ1
Entrez Gene ID: (Dog) 476968, (Human) 5911, (Mouse) 76108, (Xenopus) 414291
positive regulation of protein phosphorylation
signal transduction
small GTPase mediated signal transduction
metabolic process
microvillus assembly
negative regulation of cell migration
actin cytoskeleton reorganization
positive regulation of protein autophosphorylation
Rap protein signal transduction
cellular protein localization
cellular response to drug
establishment of protein localization
regulation of JNK cascade
regulation of dendrite morphogenesis
protein localization to plasma membrane
establishment of epithelial cell apical/basal polarity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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