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Invitrogen
RAPGEF3 Polyclonal Antibody
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Product Details
PA1-29018
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Horse,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 526-541 of Epac1 protein, peptide was covalently modified.
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
tris glycine, pH 7.4-7.9, with 30% glycerol, 0.5% BSA
Contains
0.02% Sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2238215
Product Specific Information
PA1-29018 detects Epac1 from human, rat, mouse samples.
Target Information
Gene ontology (GO) annotation includes small GTPase mediated signal transduction. Target protein binds cAMP and activates the Ras superfamily guanine nucleotide binding protein (Rap1A)in a PKA-independent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 9330170P05Rik; cAMP-GEFI; cAMP-regulated guanine nucleotide exchange factor I; cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI); EPAC 1; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; MGC21410; Rap guanine nucleotide exchange factor (GEF) 3; Rap guanine nucleotide exchange factor 3; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
Gene Aliases: 2310016P22Rik; 9330170P05Rik; bcm910; CAMP-GEFI; CGEF1; EPAC; EPAC1; HSU79275; RAPGEF3
UniProt ID: (Human) O95398, (Rat) Q9Z1C8, (Mouse) Q8VCC8
Entrez Gene ID: (Human) 10411, (Rat) 59326, (Mouse) 223864
angiogenesis
Rap protein signal transduction
positive regulation of peptidyl-serine phosphorylation
negative regulation of syncytium formation by plasma membrane fusion
positive regulation of GTPase activity
positive regulation of angiogenesis
regulation of protein kinase activity
positive regulation of protein export from nucleus
positive regulation of stress fiber assembly
positive regulation of syncytium formation by plasma membrane fusion
establishment of endothelial barrier
cellular response to cAMP
positive regulation of protein acetylation
regulation of actin cytoskeleton reorganization
regulation of histone H3-K9 acetylation
regulation of protein phosphorylation
positive regulation of protein phosphorylation
small GTPase mediated signal transduction
positive regulation of smooth muscle cell migration
positive regulation of ATPase activity
negative regulation of collagen biosynthetic process
intracellular signal transduction
positive regulation of cell size
positive regulation of transcription from RNA polymerase II promoter
positive regulation of binding
positive regulation of calcium ion transport
negative regulation of cell death
positive regulation of actin cytoskeleton reorganization
signal transduction
brain development
cell proliferation
negative regulation of cardiac muscle cell apoptotic process
cAMP-mediated signaling
spinal cord development
positive regulation of cAMP catabolic process
response to nicotine
cellular response to drug
regulation of insulin secretion
artery development
cellular response to transforming growth factor beta stimulus
liver regeneration
positive regulation of GTP binding
positive regulation of calcium ion transmembrane transport
positive regulation of hydrogen:potassium-exchanging ATPase activity
cellular response to L-dopa
dorsal root ganglion development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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