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Abnova
RAPGEF5 Monoclonal Antibody (2E4)
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Product Details
H00009771-M09
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
2E4
Immunogen
RAPGEF5 (AAH39203, 1 a.a. approximately 444 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MGSSRLRVFD PHLERKDSAA ALSDRELPLP TFDVPYFKYI DEEDEDDEWS SRSQSSTEDD SVDSLLSDRY VVVSGTPEKI LEHLLNDLHL EEVQDKETET LLDDFLLTYT VFMTTDDLCQ ALLRHYSAKK YQGKEENSDV PRRKRKVLHL VSQWIALYKD WLPEDEHSKM FLKTIYRNVL DDVYEYPILE KELKEFQKIL GMHRRHTVDE YSPQKKNKAL FHQFSLKENW LQHRGTVTET EEIFCHVYIT EHSYVSVKAK VSSIAQEILL CSQLGKRVQL VKKFIKIAAH CKAQRNLNSF FAIVMGLNTA SVSRLSQTWE KIPGKFRKLF SELESLTDPS LNHKAYRDAF KKMKPPKIPF VPLLLKDVTF IHEGNKTFLD NLVNFEKLHM IADTVRTLRH CRTNQFGDLS PKEHQELKSY VNHLYVIDSQ QALFELSHRI EPRV
Target Information
Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as Repac, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation. Repac, also known as Rap guanine nucleotide exchange factor 5 (RAPGEF5), is a 580 amino acid protein that is expressed in brain and testis, with weaker expression in heart, placenta, lung, pancreas and small intestine. Existing as two alternatively spliced isoforms, the Repac gene is conserved in cow, mouse and rat. The gene that encodes Repac maps to human chromosome 7p15.3, with high expression of this region linking to positive response to erlotinib therapy for those with non-small-cell lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Guanine nucleotide exchange factor for Rap1; M-Ras-regulated GEF; M-Ras-regulated Rap GEF; MR-GEF; Rap guanine nucleotide exchange factor (GEF) 5; Rap guanine nucleotide exchange factor 5; Related to Epac; Repac; tcag7.1034
Gene Aliases: GFR; KIAA0277; MR-GEF; MRGEF; RAPGEF5; REPAC
UniProt ID: (Human) Q92565
Entrez Gene ID: (Human) 9771
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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