Invitrogen

RAR gamma-1,2 Recombinant Rabbit Monoclonal Antibody (9K3Y1)

View all (2) RAR gamma-1,2 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-55370

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

9K3Y1

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RARG.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.03 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

RRID

AB_3667611

Product Specific Information

Immunogen Sequence: MATNKERLFA AGALGPGSGY PGAGFPFAFP GALRGSPPFE MLSPSFRGLG QPDLPKEMAS LSVETQSTSS EEMVPSSPSP PPPPRVYKPC FVCNDKSSGY

Target Information

Retinoic acid, a metabolite of vitamin A, is necessary for normal organogenesis but acts as a teratogen at high levels during embryonic and fetal development. Retinoic acid functions through its interaction with the nuclear protein, retinoic acid receptor (RAR). RAR belongs to the steroid and thyroid hormone superfamily of nuclear receptor proteins which exert their effects by binding to specific DNA response elements, thus regulating gene expression in target cells. RAR exists as three major subtypes: alpha, beta and gamma. Two main isoforms of RAR gamma exist: RAR gamma-1 has been found to be predominantly expressed in skin, while RAR gamma-2 has been found early in embryogenesis and in embryonal carcinoma cells. RAR gamma is also known as RARD. The corresponding gene for the retinoic acid receptor gamma 1 is NR1B3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Nuclear receptor subfamily 1 group B member 3; RAR gamma 2; RAR-gamma; retinoic acid nuclear receptor gamma variant 1; retinoic acid nuclear receptor gamma variant 2; Retinoic acid receptor gamma; retinoic acid receptor gamma 4; retinoic acid receptor, gamma

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Gene Aliases: NR1B3; RAR-gamma; RARC; RARD; RARG; RARgamma2

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UniProt ID: (Human) P13631, (Mouse) P18911

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Entrez Gene ID: (Human) 5916, (Mouse) 19411, (Rat) 685072

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity retinoic acid receptor activity protein binding zinc ion binding retinoid X receptor binding sequence-specific DNA binding metal ion binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter neural tube closure glandular epithelial cell development retinal pigment epithelium development growth plate cartilage chondrocyte growth transcription initiation from RNA polymerase II promoter positive regulation of cell proliferation negative regulation of cell proliferation regulation of cell size anterior/posterior pattern specification embryonic camera-type eye development regulation of myelination negative regulation of chondrocyte differentiation response to retinoic acid embryonic hindlimb morphogenesis multicellular organism growth positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of programmed cell death steroid hormone mediated signaling pathway regulation of myeloid cell differentiation positive regulation of transcription from RNA polymerase II promoter embryonic eye morphogenesis retinoic acid receptor signaling pathway canonical Wnt signaling pathway face development trachea cartilage development prostate gland epithelium morphogenesis Harderian gland development cellular response to retinoic acid chondrocyte development growth plate cartilage development transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter regulation of gene expression positive regulation of gene expression camera-type eye development negative regulation of cell differentiation reproductive structure development gland development retina development in camera-type eye limb development bone development bone morphogenesis epithelium development negative regulation of cartilage development
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