Invitrogen

RARA/RARB Polyclonal Antibody

View all (2) RARA/RARB antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-115840

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human RARA(Accession P10276), corresponding to amino acid residues P73-T123.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2900474

Product Specific Information

Antibody detects endogenous levels of total Retinoic Acid Receptor alpha/beta.

Target Information

Retinoic acid, a metabolite of vitamin A, is necessary for normal organogenesis but acts as a teratogen at high levels during embryonic and fetal development. Retinoic acid functions through its interaction with the nuclear protein, retinoic acid receptor (RAR). RAR belongs to the steroid and thyroid hormone superfamily of nuclear receptor proteins which exert their effects by binding to specific DNA response elements, thus regulating gene expression in target cells. RAR exists as three major subtypes: alpha, beta and gamma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HBV-activated protein; hepatitis B virus activated protein; Nuclear receptor subfamily 1 group B member 1; Nuclear receptor subfamily 1 group B member 2; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; RAR alpha 1; RAR-alpha; RAR-beta; RAR-epsilon; retinoic acid; retinoic acid nuclear receptor alpha variant 1; retinoic acid nuclear receptor alpha variant 2; retinoic acid receptor; Retinoic acid receptor alpha; Retinoic acid receptor beta; retinoic acid receptor, alpha polypeptide; retinoic acid receptor, beta polypeptide

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Gene Aliases: A830025K23; HAP; MCOPS12; NR1B1; NR1B2; RAR; RARA; RARalpha1; RARB; RARbeta1; RRB2

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UniProt ID: (Human) P10276, (Human) P10826, (Mouse) P11416, (Mouse) P22605

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Entrez Gene ID: (Human) 5914, (Human) 5915, (Rat) 24705, (Mouse) 19401, (Rat) 24706, (Mouse) 218772

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Function(s)
translation repressor activity, nucleic acid binding RNA polymerase II regulatory region sequence-specific DNA binding retinoic acid binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity retinoic acid receptor activity transcription coactivator activity transcription corepressor activity receptor binding protein binding transcription factor binding drug binding zinc ion binding enzyme binding protein domain specific binding chromatin DNA binding histone deacetylase binding protein kinase B binding retinoic acid-responsive element binding protein heterodimerization activity mRNA 5'-UTR binding protein kinase A binding alpha-actinin binding DNA binding protein complex binding retinoid X receptor binding RNA polymerase II regulatory region DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding phosphatidylinositol 3-kinase regulator activity sequence-specific DNA binding transcription regulatory region DNA binding regulatory region DNA binding metal ion binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter ureteric bud development glandular epithelial cell development outflow tract septum morphogenesis retinal pigment epithelium development growth plate cartilage development transcription, DNA-templated regulation of transcription, DNA-templated positive regulation of cell proliferation negative regulation of cell proliferation striatum development neurogenesis regulation of myelination negative regulation of chondrocyte differentiation embryonic hindlimb morphogenesis multicellular organism growth positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of programmed cell death steroid hormone mediated signaling pathway positive regulation of neuron differentiation positive regulation of transcription from RNA polymerase II promoter embryonic eye morphogenesis retinoic acid receptor signaling pathway embryonic digestive tract development ventricular cardiac muscle cell differentiation retina development in camera-type eye bone development negative regulation of cartilage development neural tube closure liver development transcription from RNA polymerase II promoter protein phosphorylation signal transduction germ cell development spermatogenesis female pregnancy male gonad development positive regulation of gene expression negative regulation of gene expression positive regulation of phosphatidylinositol 3-kinase signaling negative regulation of translation hippocampus development intracellular estrogen receptor signaling pathway prostate gland development regulation of granulocyte differentiation negative regulation of granulocyte differentiation embryonic camera-type eye development response to estradiol response to retinoic acid negative regulation of interferon-gamma production negative regulation of tumor necrosis factor production positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of interleukin-5 production response to vitamin A response to cytokine regulation of apoptotic process apoptotic cell clearance regulation of phosphatidylinositol 3-kinase activity response to ethanol negative regulation of cell differentiation positive regulation of T-helper 2 cell differentiation positive regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of translational initiation regulation of synaptic plasticity positive regulation of binding positive regulation of protein kinase B signaling Sertoli cell fate commitment limb development face development trachea cartilage development chondroblast differentiation positive regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to retinoic acid cellular response to estrogen stimulus transcription initiation from RNA polymerase II promoter regulation of transcription from RNA polymerase II promoter
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