Invitrogen

RARB Monoclonal Antibody (336)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA1-4670

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (IHC)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Rat

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

336

Immunogen

Synthetic peptide corresponding to the N-terminal region of human RARB conjugated to KLH
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Protein G

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_560887

Product Specific Information

This antibody is predicted to react with canine, guinea pig, mouse and non-human primate based on 100% sequence homology.

This antibody is specific for the ~48 kDa RXR-b protein.

Target Information

Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: HBV-activated protein; hepatitis B virus activated protein; Nuclear receptor subfamily 1 group B member 2; RAR beta; RAR-b; RAR-beta; RAR-Beta2; RAR-Beta4; RAR-epsilon; retinoic acid; retinoic acid receptor; Retinoic acid receptor beta; retinoic acid receptor, beta polypeptide

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Gene Aliases: HAP; MCOPS12; NR1B2; RARB; RARbeta1; RRB2

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UniProt ID: (Human) P10826

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Entrez Gene ID: (Human) 5915, (Rat) 24706

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding DNA binding steroid hormone receptor activity retinoic acid receptor activity drug binding zinc ion binding protein complex binding retinoid X receptor binding transcription factor activity, sequence-specific DNA binding protein binding sequence-specific DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter ureteric bud development glandular epithelial cell development outflow tract septum morphogenesis retinal pigment epithelium development growth plate cartilage development transcription, DNA-templated regulation of transcription, DNA-templated positive regulation of cell proliferation negative regulation of cell proliferation striatum development neurogenesis regulation of myelination negative regulation of chondrocyte differentiation embryonic hindlimb morphogenesis multicellular organism growth positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of programmed cell death steroid hormone mediated signaling pathway positive regulation of neuron differentiation positive regulation of transcription from RNA polymerase II promoter embryonic eye morphogenesis retinoic acid receptor signaling pathway embryonic digestive tract development ventricular cardiac muscle cell differentiation retina development in camera-type eye bone development negative regulation of cartilage development transcription initiation from RNA polymerase II promoter signal transduction
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