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Product Details
66815-1-IG
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1C8G4
Immunogen
RARS Fusion Protein Ag26399 (1-190 aa encoded by BC000528)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MDVLVSECS ARLLQQEEEI KSLTAEIDRL KNCGCLGASP NLEQLQEENL KLKYRLNILR KSLQAERNKP TKNMINIISR LQEVFGHAIK AAYPDLENPP LLVTPSQQAK FGDYQCNSAM GISQMLKTKE QKVNPREIAE NITKHLPDNE CIEKVEIAGP GFINVHLRKD FVSEQLTSLL VNGVQLPALG E (1-190 aa encoded by BC000528)
Target Information
The fidelity of protein synthesis requires efficient discrimination of amino acid substrates by aminoacyl-tRNA synthetases. ArgRS (Arginyl-tRNA synthetase), also known as RARS or DALRD1, belongs to the class-I aminoacyl-tRNA synthetase family that includes the related proteins, LeuRS, ValRS and IleRS. These proteins are large monomeric proteins and play a major role in catalyzing the aminoacylation of tRNA by their cognate amino acid. ArgRS localizes to the cytoplasm and exists as a monomer but can also associate with other tRNA synthetases and auxiliary proteins to form a multisubunit complex. In the presence of ATP, arginine (Arg) and tRNA, ArgRS joins Arg to tRNA(Arg) at its synthetic active site. Two cytoplasmic forms of ArgRS have been described in mammals, differing by the addition of a 73 amino acid sequence that is required for ArgRS assembly into the multisubunit complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: arginine tRNA ligase 1, cytoplasmic; Arginine--tRNA ligase, cytoplasmic; Arginyl-tRNA synthetase; arginyl-tRNA synthetase, cytoplasmic; ArgRS; MGC8641
Gene Aliases: 2610011N19Rik; 2610037E21Rik; AL033339; ArgRS; AW985894; DALRD1; HLD9; RARS; RARS1
UniProt ID: (Human) P54136, (Rat) P40329, (Mouse) Q9D0I9
Entrez Gene ID: (Human) 5917, (Rat) 287191, (Mouse) 104458
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