Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Abnova
RASA1 Polyclonal Antibody, MaxPab™
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
H00005921-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RASA1 (NP_072179.1, 1 a.a. approximately 870 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Cell lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MKGWYHGKLD RTIAEERLRQ AGKSGSYLIR ESDRRPGSFV LSFLSQMNVV NHFRIIAMCG DYYIGGRRFS SLSDLIGYYS HVSCLLKGEK LLYPVAPPEP VEDRRRVRAI LPYTKVPDTD EISFLKGDMF IVHNELEDGW MWVTNLRTDE QGLIVEDLVE EVGREEDPHE GKIWFHGKIS KQEAYNLLMT VGQVCSFLVR PSDNTPGDYS LYFRTNENIQ RFKICPTPNN QFMMGGRYYN SIGDIIDHYR KEQIVEGYYL KEPVPMQDQE QVLNDTVDGK EIYNTIRRKT KDAFYKNIVK KGYLLKKGKG KRWKNLYFIL EGSDAQLIYF ESEKRATKPK GLIDLSVCSV YVVHDSLFGR PNCFQIVVQH FSEEHYIFYF AGETPEQAED WMKGLQAFCN LRKSSPGTSN KRLRQVSSLV LHIEEAHKLP VKHFTNPYCN IYLNSVQVAK THAREGQNPV WSEEFVFDDL PPDINRFEIT LSNKTKKSKD PDILFMRCQL SRLQKGHATD EWFLLSSHIP LKGIEPGSLR VRARYSMEKI MPEEEYSEFK ELILQKELHV VYALSHVCGQ DRTLLASILL RIFLHEKLES LLLCTLNDRE ISMEDEATTL FRATTLASTL MEQYMKATAT QFVHHALKDS ILKIMESKQS CELSPSKLEK NEDVNTNLTH LLNILSELVE KIFMASEILP PTLRYIYGCL QKSVQHKWPT NTTMRTRVVS GFVFLRLICP AILNPRMFNI ISDSPSPIAA RTLILVAKSV QNLANLVEFG AKEPYMEGVN PFIKSNKHRM IMFLDELGNV PELPDTTEHS RTDLSRDLAA LHEICVAHSD ELRTLSNERG AQQHVLKKLL AITELLQQKQ NQYTKTNDVR
Target Information
TACC1 is located on 8p11 chromosomal region that is amplified in approximately 15% of all breast tumor samples. The short arm of chromosome 8 also contains FGFR1 whose expression is enhanced in most breast cancer tumors. TACC family members, TACC1, TACC2, and TACC3, map very closely to the corresponding FGFR1, FGFR2, FGFR3 genes on chromosomes 4,8, and 10. Subsequently, since they are phylogenetically related, it is proposed that TACC and FGFR have similar roles in cell growth and differentiation. Also, TACC1 contains a conserved C-terminal region as in the Drosophila homolog, D-TACC. It has been shown that D-TACC is necessary for normal spindle function, and the mammalian TACC proteins appears to interact with centrosomes and microtubules in a similar manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: GAP; p120 RAS GTPase activating protein; p120GAP; Ras GTPase-activating protein 1; Ras p21 protein activator; RAS p21 protein activator (GTPase activating protein) 1; triphosphatase-activating protein
Gene Aliases: CM-AVM; CMAVM; GAP; p120; p120GAP; p120RASGAP; PKWS; RASA; RASA1; RASGAP
UniProt ID: (Human) P20936
Entrez Gene ID: (Human) 5921
MAPK cascade
mitotic cytokinesis
vasculogenesis
negative regulation of cell-matrix adhesion
negative regulation of cell adhesion
signal transduction
regulation of cell shape
embryo development
regulation of actin filament polymerization
intracellular signal transduction
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
negative regulation of Ras protein signal transduction
ephrin receptor signaling pathway
blood vessel morphogenesis
regulation of RNA metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support