Proteintech

RASGRF1 Polyclonal Antibody

FIGURE: 1 / 3

RASGRF1 Antibody (12958-1-AP) in WB

Human brain tissue were subjected to SDS PAGE followed by western blot with 12958-1-AP (RASGRF1 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

RASGRF1 Antibody in Immunoprecipitation (IP)

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Product Details

12958-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RASGRF1 Fusion Protein Ag4072 (832-1181 aa encoded by BC040275)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: QSDDGDTET SPTKSPTTPK SVKNKNSSEF PLFSYNNGVV MTSCRELDNN RSALSAASAF AIATAGANEG TPNKEKYRRM SLASAGFPPD QRNGDKEFVI RRAATNRVLN VLRHWVSKHS QDFETNDELK CKVIGFLEEV MHDPELLTQE RKAAANIIRT LTQEDPGDNQ ITLEEITQMA EGVKAEPFEN HSALEIAEQL TLLDHLVFKK IPYEEFFGQG WMKLEKNERT PYIMKTTKHF NDISNLIASE IIRNEDINAR VSAIEKWVAV ADICRCLHNY NAVLEITSSM NRSAIFRLKK TWLKVSKQVR AGGWHHCLPG AGLGLGQEDP WAGHWASTSG QRTGLRSNTP R (832-1181 aa encoded by BC040275)

Target Information

RASGRF1 is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. Studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Upregulation of RasGRF1 ameliorates spatial cognitive dysfunction in mice after chronic cerebral hypoperfusion.

Aging

Yang LJ,Wu W,Jiang WR,Zhu CL,Yao ZH

Wed Apr 12 00:00:00 UTC 2023

Upregulation of RasGRF1 ameliorates spatial cognitive dysfunction in mice after chronic cerebral hypoperfusion.

Aging

Yang LJ,Wu W,Jiang WR,Zhu CL,Yao ZH

Wed Apr 12 00:00:00 UTC 2023

Anthocyanins from Black Chokeberry (Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain.

Journal of agricultural and food chemistry

Wei J,Zhang G,Zhang X,Xu D,Gao J,Fan J,Zhou Z

Wed Jul 26 00:00:00 UTC 2017

Anthocyanins from Black Chokeberry (Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain.

Journal of agricultural and food chemistry

Wei J,Zhang G,Zhang X,Xu D,Gao J,Fan J,Zhou Z

Wed Jul 26 00:00:00 UTC 2017

Ginsenoside PPD's Antitumor Effect via Down-Regulation of mTOR Revealed by Super-Resolution Imaging.

Molecules (Basel, Switzerland)

Teng B,Jiang J,Zhao L,Gao J,Chen J,Liu Z,Wang H,Lu B

Sun Mar 19 00:00:00 UTC 2017

Ginsenoside PPD's Antitumor Effect via Down-Regulation of mTOR Revealed by Super-Resolution Imaging.

Molecules (Basel, Switzerland)

Teng B,Jiang J,Zhao L,Gao J,Chen J,Liu Z,Wang H,Lu B

Sun Mar 19 00:00:00 UTC 2017

Modulation of B-cell receptor and microenvironment signaling by a guanine exchange factor in B-cell malignancies.

Cancer biology & medicine

Liao W,Sharma S

Wed Jun 01 00:00:00 UTC 2016

Modulation of B-cell receptor and microenvironment signaling by a guanine exchange factor in B-cell malignancies.

Cancer biology & medicine

Liao W,Sharma S

Wed Jun 01 00:00:00 UTC 2016

DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.

Medical oncology (Northwood, London, England)

Huang W,Liu J,Feng X,Chen H,Zeng L,Huang G,Liu W,Wang L,Jia W,Chen J,Ren C

Wed Apr 01 00:00:00 UTC 2015

DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.

Medical oncology (Northwood, London, England)

Huang W,Liu J,Feng X,Chen H,Zeng L,Huang G,Liu W,Wang L,Jia W,Chen J,Ren C

Wed Apr 01 00:00:00 UTC 2015

Amplification of B cell receptor-Erk signaling by Rasgrf-1 overexpression in chronic lymphocytic leukemia.

Leukemia & lymphoma

Liao W,Jordaan G,Coriaty N,Sharma S

Mon Dec 01 00:00:00 UTC 2014

Amplification of B cell receptor-Erk signaling by Rasgrf-1 overexpression in chronic lymphocytic leukemia.

Leukemia & lymphoma

Liao W,Jordaan G,Coriaty N,Sharma S

Mon Dec 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: ASPP1; CDC25Mm; GNRP; guanine nucleotide exchange factor; guanine nucleotide-releasing factor 1; guanine nucleotide-releasing factor, 55 kD; Guanine nucleotide-releasing protein; KIAA0771; P140 RAS-GRF; PPP1R13B; Ras guanine release factor beta; Ras protein-specific guanine nucleotide-releasing factor 1; Ras-GRF1; Ras-specific guanine nucleotide-releasing factor 1; Ras-specific guanine nucleotide-releasing factor, CDC25 homolog; Ras-specific nucleotide exchange factor CDC25

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Gene Aliases: AI844718; CDC25; CDC25L; CDC25Mm; GNRP; GRF1; GRF55; Grfbeta; H-GRF55; p190; P190-A; p190RhoGEF; PP13187; Ras-GRF1; RASGRF1

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UniProt ID: (Human) Q13972, (Mouse) P27671, (Rat) P28818

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Entrez Gene ID: (Human) 5923, (Mouse) 19417, (Rat) 192213

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Function(s)

guanyl-nucleotide exchange factor activity Ras guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity glutamate receptor binding protein binding protein C-terminus binding protein kinase binding

Process(es)

small GTPase mediated signal transduction cell proliferation neuron projection development regulation of Rac protein signal transduction regulation of Rho protein signal transduction intracellular signal transduction positive regulation of GTPase activity regulation of Ras protein signal transduction positive regulation of Ras protein signal transduction regulation of synaptic plasticity regulation of neuronal synaptic plasticity activation of GTPase activity regulation of N-methyl-D-aspartate selective glutamate receptor activity MAPK cascade signal transduction long-term memory

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RASGRF1 Polyclonal Antibody

RASGRF1 Antibody (12958-1-AP) in WB

Product Details

12958-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunoprecipitation (IP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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