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Invitrogen
RASGRP1 Polyclonal Antibody
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RASGRP1 Antibody (PA5-25750) in IHC (P)
Immunohistochemistry analysis of RASGRP1 in formalin fixed and paraffin embedded human brain tissue. Samples were incubated with RASGRP1 polyclonal antibody (Product # PA5-25750) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Product Details
PA5-25750
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 495-521 amino acids from the central region of human RASGRP1
Conjugate
Form
Liquid
Concentration
1.8 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2543250
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways. Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Calcium and DAG-regulated guanine nucleotide exchange factor II; calcium- and diacylglycerol-regulated guanine nucleotide exchange factor II; CalDAG-GEFII; guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A; ras activator RasGRP; RAS guanyl nucleotide-releasing protein 1; RAS guanyl releasing protein 1 (calcium and DAG-regulated); Ras guanyl-releasing protein; RAS guanyl-releasing protein 1
Gene Aliases: CALDAG-GEFI; CALDAG-GEFII; hRasGRP1; RASGRP; RASGRP1; V
UniProt ID: (Human) O95267
Entrez Gene ID: (Human) 10125
MAPK cascade
cytokine production
positive regulation of protein phosphorylation
inflammatory response to antigenic stimulus
signal transduction
Ras protein signal transduction
regulation of phosphatidylinositol 3-kinase signaling
cell differentiation
secretory granule localization
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of tumor necrosis factor production
positive regulation of natural killer cell differentiation
positive regulation of T cell differentiation in thymus
mast cell degranulation
positive regulation of MAP kinase activity
positive regulation of GTPase activity
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of JNK cascade
positive regulation of Ras protein signal transduction
vesicle transport along microtubule
protein oligomerization
regulation of ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
activation of GTPase activity
regulation of phospholipase C activity
regulation of p38MAPK cascade
positive regulation of interferon-gamma secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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