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Product Details
H00115727-M01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
1F3
Immunogen
RASGRP4 (NP_733748, 574 a.a. approximately 673 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: CGLCCHKHCR DQVKVECKKR PGAKGDAGPP GAPVPSTPAP HASCGSEENH SYTLSLEPET GCQLRHAWTQ TESPHPSWET DTVPCPVMDP PSTASSKLDS
Target Information
The RASGRP4 (RAS Guanyl Releasing Protein 4) gene encodes a guanine nucleotide exchange factor (GEF) that specifically activates RAS proteins by facilitating the exchange of GDP for GTP. Located on chromosome 19, RASGRP4 is expressed primarily in hematopoietic cells, including mast cells and certain myeloid cells. The protein contains a diacylglycerol (DAG)-binding C1 domain, a Ras exchange motif, and a CDC25 domain, which are essential for its activation and function. RASGRP4 plays a pivotal role in signal transduction pathways that regulate cell proliferation, differentiation, and survival. Dysregulation of RASGRP4 has been linked to various diseases, including inflammatory disorders and cancers, particularly those involving the hematopoietic system. Studies have shown that overexpression or mutations in RASGRP4 can lead to aberrant RAS signaling, contributing to oncogenesis and disease progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: guanyl nucleotide releasing protein 4; RAS guanyl-releasing protein 4
Gene Aliases: RASGRP4
UniProt ID: (Human) Q8TDF6
Entrez Gene ID: (Human) 115727
MAPK cascade
transmembrane receptor protein tyrosine kinase signaling pathway
activation of phospholipase C activity
small GTPase mediated signal transduction
regulation of G-protein coupled receptor protein signaling pathway
cell proliferation
response to extracellular stimulus
cell growth
myeloid cell differentiation
positive regulation of GTPase activity
positive regulation of Ras protein signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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