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Product Details
H00054922-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RASIP1 (AAH21860.1, 1 a.a. approximately 317 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MLWMANTTEL LSFVQEKVLE MEKEADQEDP QLCNDLELCD EAMALLDEVI MCTFQQSVYY LTKTLYSTLP ALLDSNPFTA GAELPGPGAE LGAMPPGLRP TLGVFQAALE LTSQCELHPD LVSQTFGYLF FFSNASLLNS LMERGQGRPF YQWSRAVQIR TNLDLVLDWL QGAGLGDIAT EFFRKLSMAV NLLCVPRTSL LKASWSSLRT DHPTLTPAQL HHLLSHYQLG PGRGPPAAWD PPPAEREAVD TGDIFESFSS HPPLILPLGS SRLRLTGPVT DDALHRELRR LRRLLWDLEQ QELPANYRHG PPVATSP
Target Information
Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells. May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Rain; Ras-interacting protein 1
Gene Aliases: RAIN; RASIP1
UniProt ID: (Human) Q5U651
Entrez Gene ID: (Human) 54922
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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