Proteintech

RASSF6 Polyclonal Antibody

RASSF6 Antibody in Immunocytochemistry (ICC/IF)

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RASSF6 Antibody (11921-1-AP) in ICC/IF

Immunofluorescent analysis of Hela cells, using RASSF6 antibody 11921-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

RASSF6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

RASSF6 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11921-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RASSF6 Fusion Protein Ag2565 (1-300 aa encoded by BC058835)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.53 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAHQYPSWI FINEKTFITR EQLNSLLKTY NIFYENQKNL HILYGETEDG KLIVEGMLDI FWGVKRPIQL KIQDEKPFSS FTSMKSSDVF SSKGMTRWGE FDDLYRISEL DRTQIPMSEK RNSQEDYLPY HSNTLKPHAK DEPDSPVLYR TMSEAALVRK RMKPLMMDRK ERQKNRASIN GHFYNHEIEN SPQDFALHII FATGEQRRLK KTDIPLLQRL LQGPSEKNAR IFLMDKDAEE ISSDVAQYIN FHFSLLESIL QRLNEEEKRE IQRIVTKFNK EKAIILKCLQ NKLVIKTETT V (1-300 aa encoded by BC058835)

Target Information

RASSF6 is a member of the RAS association domain family of RAS effectors/tumor suppressors that mediate some of the growth inhibitory properties of RAS oncogenes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

DNA Damage Triggers the Nuclear Accumulation of RASSF6 Tumor Suppressor Protein via CDK9 and BAF53 To Regulate p53 Target Gene Transcription.

Molecular and cellular biology

Kuleape JA,Hossain S,Sinclear CK,Shimizu T,Iwasa H,Maruyama J,Arimoto-Matsuzaki K,Nishina H,Hata Y

Thu Feb 17 00:00:00 UTC 2022

DNA Damage Triggers the Nuclear Accumulation of RASSF6 Tumor Suppressor Protein via CDK9 and BAF53 To Regulate p53 Target Gene Transcription.

Molecular and cellular biology

Kuleape JA,Hossain S,Sinclear CK,Shimizu T,Iwasa H,Maruyama J,Arimoto-Matsuzaki K,Nishina H,Hata Y

Thu Feb 17 00:00:00 UTC 2022

Characterization of mouse embryonic fibroblasts derived from Rassf6 knockout mice shows the implication of Rassf6 in the regulation of NF-κB signaling.

Genes to cells : devoted to molecular & cellular mechanisms

Morishita M,Arimoto-Matsuzaki K,Kitamura M,Niimura K,Iwasa H,Maruyama J,Hiraoka Y,Yamamoto K,Kitagawa M,Miyamura N,Nishina H,Hata Y

Wed Dec 01 00:00:00 UTC 2021

MiR-496 promotes migration and epithelial-mesenchymal transition by targeting RASSF6 in colorectal cancer.

Journal of cellular physiology

Wang H,Yan B,Zhang P,Liu S,Li Q,Yang J,Yang F,Chen E

Sat Feb 01 00:00:00 UTC 2020

RASSF6-TRIM16 axis promotes cell proliferation, migration and invasion in esophageal squamous cell carcinoma.

Journal of genetics and genomics = Yi chuan xue bao

Zheng L,Zhao Z,Rong L,Xue L,Song Y

Sun Oct 20 00:00:00 UTC 2019

RASSF6-TRIM16 axis promotes cell proliferation, migration and invasion in esophageal squamous cell carcinoma.

Journal of genetics and genomics = Yi chuan xue bao

Zheng L,Zhao Z,Rong L,Xue L,Song Y

Sun Oct 20 00:00:00 UTC 2019

RASSF6 Is Downregulated In Human Bladder Cancers And Regulates Doxorubicin Sensitivity And Mitochondrial Membrane Potential Via The Hippo Signaling Pathway.

OncoTargets and therapy

Tan S,Bian X,Wu B,Chen X

Mon Apr 11 00:00:00 UTC 2022

Downregulation of RASSF6 promotes breast cancer growth and chemoresistance through regulation of Hippo signaling.

Biochemical and biophysical research communications

He Z,Zhao TT,Jin F,Li JG,Xu YY,Dong HT,Liu Q,Xing P,Zhu GL,Xu H,Miao ZF

Tue Sep 18 00:00:00 UTC 2018

Downregulation of RASSF6 promotes breast cancer growth and chemoresistance through regulation of Hippo signaling.

Biochemical and biophysical research communications

He Z,Zhao TT,Jin F,Li JG,Xu YY,Dong HT,Liu Q,Xing P,Zhu GL,Xu H,Miao ZF

Tue Sep 18 00:00:00 UTC 2018

Downregulation of RASSF6 promotes breast cancer growth and chemoresistance through regulation of Hippo signaling.

Biochemical and biophysical research communications

He Z,Zhao TT,Jin F,Li JG,Xu YY,Dong HT,Liu Q,Xing P,Zhu GL,Xu H,Miao ZF

Tue Sep 18 00:00:00 UTC 2018

Downregulation of RASSF6 promotes breast cancer growth and chemoresistance through regulation of Hippo signaling.

Biochemical and biophysical research communications

He Z,Zhao TT,Jin F,Li JG,Xu YY,Dong HT,Liu Q,Xing P,Zhu GL,Xu H,Miao ZF

Tue Sep 18 00:00:00 UTC 2018

The RASSF6 Tumor Suppressor Protein Regulates Apoptosis and Cell Cycle Progression via Retinoblastoma Protein.

Molecular and cellular biology

Hossain S,Iwasa H,Sarkar A,Maruyama J,Arimoto-Matsuzaki K,Hata Y

Sat Sep 01 00:00:00 UTC 2018

BCL-XL binds and antagonizes RASSF6 tumor suppressor to suppress p53 expression.

Genes to cells : devoted to molecular & cellular mechanisms

Xu X,Iwasa H,Hossain S,Sarkar A,Maruyama J,Arimoto-Matsuzaki K,Hata Y

Fri Dec 01 00:00:00 UTC 2017

BCL-XL binds and antagonizes RASSF6 tumor suppressor to suppress p53 expression.

Genes to cells : devoted to molecular & cellular mechanisms

Xu X,Iwasa H,Hossain S,Sarkar A,Maruyama J,Arimoto-Matsuzaki K,Hata Y

Fri Dec 01 00:00:00 UTC 2017

BCL-XL binds and antagonizes RASSF6 tumor suppressor to suppress p53 expression.

Genes to cells : devoted to molecular & cellular mechanisms

Xu X,Iwasa H,Hossain S,Sarkar A,Maruyama J,Arimoto-Matsuzaki K,Hata Y

Fri Dec 01 00:00:00 UTC 2017

BCL-XL binds and antagonizes RASSF6 tumor suppressor to suppress p53 expression.

Genes to cells : devoted to molecular & cellular mechanisms

Xu X,Iwasa H,Hossain S,Sarkar A,Maruyama J,Arimoto-Matsuzaki K,Hata Y

Fri Dec 01 00:00:00 UTC 2017

BCL-XL binds and antagonizes RASSF6 tumor suppressor to suppress p53 expression.

Genes to cells : devoted to molecular & cellular mechanisms

Xu X,Iwasa H,Hossain S,Sarkar A,Maruyama J,Arimoto-Matsuzaki K,Hata Y

Fri Dec 01 00:00:00 UTC 2017

BCL-XL binds and antagonizes RASSF6 tumor suppressor to suppress p53 expression.

Genes to cells : devoted to molecular & cellular mechanisms

Xu X,Iwasa H,Hossain S,Sarkar A,Maruyama J,Arimoto-Matsuzaki K,Hata Y

Fri Dec 01 00:00:00 UTC 2017

RASSF6 downregulation promotes the epithelial-mesenchymal transition and predicts poor prognosis in colorectal cancer.

Oncotarget

Zhou R,Qiu L,Liu X,Ling L,Li N,Zhou K,Sun J,Yan J,Tan C,Huang X,Han L,Yin L,Xiao G,Liu L

Tue Aug 15 00:00:00 UTC 2017

RASSF6 downregulation promotes the epithelial-mesenchymal transition and predicts poor prognosis in colorectal cancer.

Oncotarget

Zhou R,Qiu L,Liu X,Ling L,Li N,Zhou K,Sun J,Yan J,Tan C,Huang X,Han L,Yin L,Xiao G,Liu L

Tue Aug 15 00:00:00 UTC 2017

RASSF6 downregulation promotes the epithelial-mesenchymal transition and predicts poor prognosis in colorectal cancer.

Oncotarget

Zhou R,Qiu L,Liu X,Ling L,Li N,Zhou K,Sun J,Yan J,Tan C,Huang X,Han L,Yin L,Xiao G,Liu L

Tue Aug 15 00:00:00 UTC 2017

RASSF6 downregulation promotes the epithelial-mesenchymal transition and predicts poor prognosis in colorectal cancer.

Oncotarget

Zhou R,Qiu L,Liu X,Ling L,Li N,Zhou K,Sun J,Yan J,Tan C,Huang X,Han L,Yin L,Xiao G,Liu L

Tue Aug 15 00:00:00 UTC 2017

Decreased level of RASSF6 in sporadic colorectal cancer and its anti-tumor effects both in vitro and in vivo.

Oncotarget

Chen E,Yang F,He H,Lei L,Liu R,Du L,Dong J,Wang M,Yang J

Tue Apr 12 00:00:00 UTC 2016

Low RASSF6 expression in pancreatic ductal adenocarcinoma is associated with poor survival.

World journal of gastroenterology

Ye HL,Li DD,Lin Q,Zhou Y,Zhou QB,Zeng B,Fu ZQ,Gao WC,Liu YM,Chen RW,Li ZH,Chen RF

Sun Jun 07 00:00:00 UTC 2015

Low RASSF6 expression in pancreatic ductal adenocarcinoma is associated with poor survival.

World journal of gastroenterology

Ye HL,Li DD,Lin Q,Zhou Y,Zhou QB,Zeng B,Fu ZQ,Gao WC,Liu YM,Chen RW,Li ZH,Chen RF

Sun Jun 07 00:00:00 UTC 2015

Low RASSF6 expression in pancreatic ductal adenocarcinoma is associated with poor survival.

World journal of gastroenterology

Ye HL,Li DD,Lin Q,Zhou Y,Zhou QB,Zeng B,Fu ZQ,Gao WC,Liu YM,Chen RW,Li ZH,Chen RF

Sun Jun 07 00:00:00 UTC 2015

Low RASSF6 expression in pancreatic ductal adenocarcinoma is associated with poor survival.

World journal of gastroenterology

Ye HL,Li DD,Lin Q,Zhou Y,Zhou QB,Zeng B,Fu ZQ,Gao WC,Liu YM,Chen RW,Li ZH,Chen RF

Sun Jun 07 00:00:00 UTC 2015

RASSF6 exhibits promoter hypermethylation in metastatic melanoma and inhibits invasion in melanoma cells.

Epigenetics

Mezzanotte JJ,Hill V,Schmidt ML,Shinawi T,Tommasi S,Krex D,Schackert G,Pfeifer GP,Latif F,Clark GJ

Sat Nov 01 00:00:00 UTC 2014

RASSF6 exhibits promoter hypermethylation in metastatic melanoma and inhibits invasion in melanoma cells.

Epigenetics

Mezzanotte JJ,Hill V,Schmidt ML,Shinawi T,Tommasi S,Krex D,Schackert G,Pfeifer GP,Latif F,Clark GJ

Sat Nov 01 00:00:00 UTC 2014

Decreased expression of RASSF6 is a novel independent prognostic marker of a worse outcome in gastric cancer patients after curative surgery.

Annals of surgical oncology

Wen Y,Wang Q,Zhou C,Yan D,Qiu G,Yang C,Tang H,Peng Z

Thu Dec 01 00:00:00 UTC 2011

Decreased expression of RASSF6 is a novel independent prognostic marker of a worse outcome in gastric cancer patients after curative surgery.

Annals of surgical oncology

Wen Y,Wang Q,Zhou C,Yan D,Qiu G,Yang C,Tang H,Peng Z

Thu Dec 01 00:00:00 UTC 2011

Decreased expression of RASSF6 is a novel independent prognostic marker of a worse outcome in gastric cancer patients after curative surgery.

Annals of surgical oncology

Wen Y,Wang Q,Zhou C,Yan D,Qiu G,Yang C,Tang H,Peng Z

Thu Dec 01 00:00:00 UTC 2011

Decreased expression of RASSF6 is a novel independent prognostic marker of a worse outcome in gastric cancer patients after curative surgery.

Annals of surgical oncology

Wen Y,Wang Q,Zhou C,Yan D,Qiu G,Yang C,Tang H,Peng Z

Thu Dec 01 00:00:00 UTC 2011

The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias.

Molecular cancer

Hesson LB,Dunwell TL,Cooper WN,Catchpoole D,Brini AT,Chiaramonte R,Griffiths M,Chalmers AD,Maher ER,Latif F

Wed Jul 01 00:00:00 UTC 2009

The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias.

Molecular cancer

Hesson LB,Dunwell TL,Cooper WN,Catchpoole D,Brini AT,Chiaramonte R,Griffiths M,Chalmers AD,Maher ER,Latif F

Wed Jul 01 00:00:00 UTC 2009

Bioinformatics

Protein Aliases: DKFZp686K23225; putative RAS binding protein; Ras association (RalGDS/AF-6) domain family 6; Ras association (RalGDS/AF-6) domain family member 6; Ras association domain-containing protein 6

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Gene Aliases: RASSF6

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UniProt ID: (Human) Q6ZTQ3

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Entrez Gene ID: (Human) 166824

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Function(s)

protein binding

Process(es)

apoptotic process signal transduction regulation of apoptotic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RASSF6 Polyclonal Antibody

RASSF6 Antibody (11921-1-AP) in ICC/IF

Product Details

11921-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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