Product References
The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy.
Cell reports
Gallagher ER,Holzbaur ELF
Tue Feb 28 00:00:00 UTC 2023
Unique amphipathic α helix drives membrane insertion and enzymatic activity of ATG3.
Science advances
Nishimura T,Lazzeri G,Mizushima N,Covino R,Tooze SA
Fri Jun 23 00:00:00 UTC 2023
An affinity-directed phosphatase, AdPhosphatase, system for targeted protein dephosphorylation.
Cell chemical biology
Simpson LM,Fulcher LJ,Sathe G,Brewer A,Zhao JF,Squair DR,Crooks J,Wightman M,Wood NT,Gourlay R,Varghese J,Soares RF,Sapkota GP
Thu Feb 16 00:00:00 UTC 2023
ATG16L1 adopts a dual-binding site mode to interact with WIPI2b in autophagy.
Science advances
Gong X,Wang Y,Tang Y,Wang Y,Zhang M,Li M,Zhang Y,Pan L
Wed Mar 01 00:00:00 UTC 2023
CCPG1 recognizes endoplasmic reticulum luminal proteins for selective ER-phagy.
Molecular biology of the cell
Ishii S,Chino H,Ode KL,Kurikawa Y,Ueda HR,Matsuura A,Mizushima N,Itakura E
Sat Apr 01 00:00:00 UTC 2023
TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.
Molecular cell
Le Guerroué F,Bunker EN,Rosencrans WM,Nguyen JT,Basar MA,Werner A,Chou TF,Wang C,Youle RJ
Thu Mar 16 00:00:00 UTC 2023
Metamorphic proteins at the basis of human autophagy initiation and lipid transfer.
Molecular cell
Nguyen A,Lugarini F,David C,Hosnani P,Alagöz Ç,Friedrich A,Schlütermann D,Knotkova B,Patel A,Parfentev I,Urlaub H,Meinecke M,Stork B,Faesen AC
Thu Jun 15 00:00:00 UTC 2023
Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex.
Developmental cell
Kurusu R,Fujimoto Y,Morishita H,Noshiro D,Takada S,Yamano K,Tanaka H,Arai R,Kageyama S,Funakoshi T,Komatsu-Hirota S,Taka H,Kazuno S,Miura Y,Koike M,Wakai T,Waguri S,Noda NN,Komatsu M
Mon Jul 10 00:00:00 UTC 2023
NCOA4 drives ferritin phase separation to facilitate macroferritinophagy and microferritinophagy.
The Journal of cell biology
Ohshima T,Yamamoto H,Sakamaki Y,Saito C,Mizushima N
Mon Oct 03 00:00:00 UTC 2022
STING controls energy stress-induced autophagy and energy metabolism via STX17.
The Journal of cell biology
Rong Y,Zhang S,Nandi N,Wu Z,Li L,Liu Y,Wei Y,Zhao Y,Yuan W,Zhou C,Xiao G,Levine B,Yan N,Mou S,Deng L,Tang Z,Liu X,Kramer H,Zhong Q
Mon Jul 04 00:00:00 UTC 2022
Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival.
Cell reports
Li H,Li C,Zhai W,Zhang X,Li L,Wu B,Yu B,Zhang P,Li J,Cui CP,Zhang L
Tue Oct 04 00:00:00 UTC 2022
The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3.
Nature communications
Ishimura R,El-Gowily AH,Noshiro D,Komatsu-Hirota S,Ono Y,Shindo M,Hatta T,Abe M,Uemura T,Lee-Okada HC,Mohamed TM,Yokomizo T,Ueno T,Sakimura K,Natsume T,Sorimachi H,Inada T,Waguri S,Noda NN,Komatsu M
Wed Dec 21 00:00:00 UTC 2022
EPA and DHA differentially coordinate the crosstalk between host and gut microbiota and block DSS-induced colitis in mice by a reinforced colonic mucus barrier.
Food & function
Fang J,Zhang Z,Cheng Y,Yang H,Zhang H,Xue Z,Lu S,Dong Y,Song C,Zhang X,Zhou Y
Wed Apr 20 00:00:00 UTC 2022
Calcium transients on the ER surface trigger liquid-liquid phase separation of FIP200 to specify autophagosome initiation sites.
Cell
Zheng Q,Chen Y,Chen D,Zhao H,Feng Y,Meng Q,Zhao Y,Zhang H
Thu Oct 27 00:00:00 UTC 2022
Calcium transients on the ER surface trigger liquid-liquid phase separation of FIP200 to specify autophagosome initiation sites.
Cell
Zheng Q,Chen Y,Chen D,Zhao H,Feng Y,Meng Q,Zhao Y,Zhang H
Thu Oct 27 00:00:00 UTC 2022
Calcium transients on the ER surface trigger liquid-liquid phase separation of FIP200 to specify autophagosome initiation sites.
Cell
Zheng Q,Chen Y,Chen D,Zhao H,Feng Y,Meng Q,Zhao Y,Zhang H
Thu Oct 27 00:00:00 UTC 2022
Palmitic acid control of ciliogenesis modulates insulin signaling in hypothalamic neurons through an autophagy-dependent mechanism.
Cell death & disease
Ávalos Y,Hernández-Cáceres MP,Lagos P,Pinto-Nuñez D,Rivera P,Burgos P,Díaz-Castro F,Joy-Immediato M,Venegas-Zamora L,Lopez-Gallardo E,Kretschmar C,Batista-Gonzalez A,Cifuentes-Araneda F,Toledo-Valenzuela L,Rodriguez-Peña M,Espinoza-Caicedo J,Perez-Leighton C,Bertocchi C,Cerda M,Troncoso R,Parra V,Budini M,Burgos PV,Criollo A,Morselli E
Thu Jul 28 00:00:00 UTC 2022
VEGF-Mediated Augmentation of Autophagic and Lysosomal Activity in Endothelial Cells Defends against Intracellular Streptococcus pyogenes.
mBio
Lu SL,Omori H,Zhou Y,Lin YS,Liu CC,Wu JJ,Noda T
Tue Aug 30 00:00:00 UTC 2022
SHISA5/SCOTIN restrains spontaneous autophagy induction by blocking contact between the ERES and phagophores.
Autophagy
Lee JE,Kim N,Jung M,Mun JY,Yoo JY
Fri Jul 01 00:00:00 UTC 2022
Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.
Nature communications
Jin S,He X,Ma L,Zhuang Z,Wang Y,Lin M,Cai S,Wei L,Wang Z,Zhao Z,Wu Y,Sun L,Li C,Xie W,Zhao Y,Songyang Z,Peng K,Zhao J,Cui J
Sat Sep 03 00:00:00 UTC 2022
Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy.
Cell reports
Saha B,Salemi M,Williams GL,Oh S,Paffett ML,Phinney B,Mandell MA
Tue May 10 00:00:00 UTC 2022
Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy.
Cell reports
Saha B,Salemi M,Williams GL,Oh S,Paffett ML,Phinney B,Mandell MA
Tue May 10 00:00:00 UTC 2022
CCT2 is an aggrephagy receptor for clearance of solid protein aggregates.
Cell
Ma X,Lu C,Chen Y,Li S,Ma N,Tao X,Li Y,Wang J,Zhou M,Yan YB,Li P,Heydari K,Deng H,Zhang M,Yi C,Ge L
Thu Apr 14 00:00:00 UTC 2022
Disruption of actin dynamics induces autophagy of the eukaryotic chaperonin TRiC/CCT.
Cell death discovery
Date Y,Matsuura A,Itakura E
Tue Jan 25 00:00:00 UTC 2022
A new type of ERGIC-ERES membrane contact mediated by TMED9 and SEC12 is required for autophagosome biogenesis.
Cell research
Li S,Yan R,Xu J,Zhao S,Ma X,Sun Q,Zhang M,Li Y,Liu JG,Chen L,Li S,Xu K,Ge L
Tue Feb 01 00:00:00 UTC 2022
A new type of ERGIC-ERES membrane contact mediated by TMED9 and SEC12 is required for autophagosome biogenesis.
Cell research
Li S,Yan R,Xu J,Zhao S,Ma X,Sun Q,Zhang M,Li Y,Liu JG,Chen L,Li S,Xu K,Ge L
Tue Feb 01 00:00:00 UTC 2022
Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death.
Autophagy
Meyer N,Henkel L,Linder B,Zielke S,Tascher G,Trautmann S,Geisslinger G,Münch C,Fulda S,Tegeder I,Kögel D
Mon Nov 01 00:00:00 UTC 2021
Phosphoproteomic identification of ULK substrates reveals VPS15-dependent ULK/VPS34 interplay in the regulation of autophagy.
The EMBO journal
Mercer TJ,Ohashi Y,Boeing S,Jefferies HBJ,De Tito S,Flynn H,Tremel S,Zhang W,Wirth M,Frith D,Snijders AP,Williams RL,Tooze SA
Thu Jul 15 00:00:00 UTC 2021
LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13.
Autophagy
Chu Y,Kang Y,Yan C,Yang C,Zhang T,Huo H,Liu Y
Thu Jul 01 00:00:00 UTC 2021
Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity.
The Journal of biological chemistry
Faruk MO,Ichimura Y,Kageyama S,Komatsu-Hirota S,El-Gowily AH,Sou YS,Koike M,Noda NN,Komatsu M
Wed Dec 01 00:00:00 UTC 2021
The Autophagy-Initiating Protein Kinase ULK1 Phosphorylates Human Cytomegalovirus Tegument Protein pp28 and Regulates Efficient Virus Release.
Journal of virology
König P,Svrlanska A,Read C,Feichtinger S,Stamminger T
Wed Feb 24 00:00:00 UTC 2021
Atlastin 2/3 regulate ER targeting of the ULK1 complex to initiate autophagy.
The Journal of cell biology
Liu N,Zhao H,Zhao YG,Hu J,Zhang H
Mon Jul 05 00:00:00 UTC 2021
PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness.
The Journal of cell biology
Rabas N,Palmer S,Mitchell L,Ismail S,Gohlke A,Riley JS,Tait SWG,Gammage P,Soares LL,Macpherson IR,Norman JC
Mon Dec 06 00:00:00 UTC 2021
NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA.
Nature communications
Yamamoto Y,Chino H,Tsukamoto S,Ode KL,Ueda HR,Mizushima N
Wed Jun 02 00:00:00 UTC 2021
FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.
Scientific reports
Schlütermann D,Berleth N,Deitersen J,Wallot-Hieke N,Friesen O,Wu W,Stuhldreier F,Sun Y,Berning L,Friedrich A,Mendiburo MJ,Peter C,Wiek C,Hanenberg H,Stefanski A,Stühler K,Stork B
Mon Jul 05 00:00:00 UTC 2021
Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes.
Cell
Kumar S,Javed R,Mudd M,Pallikkuth S,Lidke KA,Jain A,Tangavelou K,Gudmundsson SR,Ye C,Rusten TE,Anonsen JH,Lystad AH,Claude-Taupin A,Simonsen A,Salemi M,Phinney B,Li J,Guo LW,Bradfute SB,Timmins GS,Eskelinen EL,Deretic V
Wed Nov 24 00:00:00 UTC 2021
ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation.
Developmental cell
Miao G,Zhao H,Li Y,Ji M,Chen Y,Shi Y,Bi Y,Wang P,Zhang H
Mon Feb 22 00:00:00 UTC 2021
Inhibiting autophagy increases the efficacy of low-dose photodynamic therapy.
Biochemical pharmacology
Weisheit S,Wegner CS,Ailte I,Radulovic M,Weyergang A,Selbo PK,Brech A
Wed Dec 01 00:00:00 UTC 2021
The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles.
Nature cell biology
Leidal AM,Huang HH,Marsh T,Solvik T,Zhang D,Ye J,Kai F,Goldsmith J,Liu JY,Huang YH,Monkkonen T,Vlahakis A,Huang EJ,Goodarzi H,Yu L,Wiita AP,Debnath J
Sat Feb 01 00:00:00 UTC 2020
ERdj8 governs the size of autophagosomes during the formation process.
The Journal of cell biology
Yamamoto YH,Kasai A,Omori H,Takino T,Sugihara M,Umemoto T,Hamasaki M,Hatta T,Natsume T,Morimoto RI,Arai R,Waguri S,Sato M,Sato K,Bar-Nun S,Yoshimori T,Noda T,Nagata K
Mon Aug 03 00:00:00 UTC 2020
Trans-10-hydroxy-2-decenoic acid protects against LPS-induced neuroinflammation through FOXO1-mediated activation of autophagy.
European journal of nutrition
You M,Miao Z,Tian J,Hu F
Thu Oct 01 00:00:00 UTC 2020
Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity.
Developmental cell
Chen D,Wang Z,Zhao YG,Zheng H,Zhao H,Liu N,Zhang H
Mon Dec 07 00:00:00 UTC 2020
Autophagic adaptation to oxidative stress alters peritoneal residential macrophage survival and ovarian cancer metastasis.
JCI insight
Xia H,Li S,Li X,Wang W,Bian Y,Wei S,Grove S,Wang W,Vatan L,Liu JR,McLean K,Rattan R,Munkarah A,Guan JL,Kryczek I,Zou W
Thu Sep 17 00:00:00 UTC 2020
Loss of the Essential Autophagy Regulators FIP200 or Atg5 Leads to Distinct Effects on Focal Adhesion Composition and Organization.
Frontiers in cell and developmental biology
Assar EA,Tumbarello DA
Mon Sep 28 00:00:00 UTC 2020
Aberrant autophagosome formation occurs upon small molecule inhibition of ULK1 kinase activity.
Life science alliance
Zachari M,Longo M,Ganley IG
Tue Dec 01 00:00:00 UTC 2020
Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response.
Nature cancer
Poillet-Perez L,Sharp DW,Yang Y,Laddha SV,Ibrahim M,Bommareddy PK,Hu ZS,Vieth J,Haas M,Bosenberg MW,Rabinowitz JD,Cao J,Guan JL,Ganesan S,Chan CS,Mehnert JM,Lattime EC,White E
Tue Sep 01 00:00:00 UTC 2020
Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response.
Nature cancer
Poillet-Perez L,Sharp DW,Yang Y,Laddha SV,Ibrahim M,Bommareddy PK,Hu ZS,Vieth J,Haas M,Bosenberg MW,Rabinowitz JD,Cao J,Guan JL,Ganesan S,Chan CS,Mehnert JM,Lattime EC,White E
Tue Sep 01 00:00:00 UTC 2020
Bone-derived mesenchymal stem cells alleviate compression-induced apoptosis of nucleus pulposus cells by N6 methyladenosine of autophagy.
Cell death & disease
Li G,Song Y,Liao Z,Wang K,Luo R,Lu S,Zhao K,Feng X,Liang H,Ma L,Wang B,Ke W,Yin H,Zhan S,Li S,Wu X,Zhang Y,Yang C
Thu Feb 06 00:00:00 UTC 2020
TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy.
Nature communications
Nozawa T,Sano S,Minowa-Nozawa A,Toh H,Nakajima S,Murase K,Aikawa C,Nakagawa I
Fri Feb 07 00:00:00 UTC 2020
The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1.
Molecular cell
Miao G,Zhang Y,Chen D,Zhang H
Thu Feb 06 00:00:00 UTC 2020
Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System.
Cell chemical biology
Simpson LM,Macartney TJ,Nardin A,Fulcher LJ,Röth S,Testa A,Maniaci C,Ciulli A,Ganley IG,Sapkota GP
Thu Sep 17 00:00:00 UTC 2020
10-Hydroxydecanoic acid inhibits LPS-induced inflammation by targeting p53 in microglial cells.
International immunopharmacology
You M,Miao Z,Sienkiewicz O,Jiang X,Zhao X,Hu F
Wed Jul 01 00:00:00 UTC 2020
Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components.
Cell communication and signaling : CCS
Lindner P,Christensen SB,Nissen P,Møller JV,Engedal N
Mon Jan 27 00:00:00 UTC 2020
Intrinsically Disordered Protein TEX264 Mediates ER-phagy.
Molecular cell
Chino H,Hatta T,Natsume T,Mizushima N
Thu Jun 06 00:00:00 UTC 2019
The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance.
Autophagy
Huang X,Gan G,Wang X,Xu T,Xie W
Mon Jul 01 00:00:00 UTC 2019
ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12-ATG5-ATG16L1 complex assembly and autophagy.
Cell discovery
Wible DJ,Chao HP,Tang DG,Bratton SB
Wed Aug 03 00:00:00 UTC 2022
Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform.
Developmental cell
Zachari M,Gudmundsson SR,Li Z,Manifava M,Cugliandolo F,Shah R,Smith M,Stronge J,Karanasios E,Piunti C,Kishi-Itakura C,Vihinen H,Jokitalo E,Guan JL,Buss F,Smith AM,Walker SA,Eskelinen EL,Ktistakis NT
Mon Sep 09 00:00:00 UTC 2019
Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform.
Developmental cell
Zachari M,Gudmundsson SR,Li Z,Manifava M,Cugliandolo F,Shah R,Smith M,Stronge J,Karanasios E,Piunti C,Kishi-Itakura C,Vihinen H,Jokitalo E,Guan JL,Buss F,Smith AM,Walker SA,Eskelinen EL,Ktistakis NT
Mon Sep 09 00:00:00 UTC 2019
Iron Supply via NCOA4-Mediated Ferritin Degradation Maintains Mitochondrial Functions.
Molecular and cellular biology
Fujimaki M,Furuya N,Saiki S,Amo T,Imamichi Y,Hattori N
Mon Jul 15 00:00:00 UTC 2019
Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation.
Developmental cell
Kumar S,Gu Y,Abudu YP,Bruun JA,Jain A,Farzam F,Mudd M,Anonsen JH,Rusten TE,Kasof G,Ktistakis N,Lidke KA,Johansen T,Deretic V
Mon Apr 08 00:00:00 UTC 2019
ULK1 phosphorylates Mad1 to regulate spindle assembly checkpoint.
Nucleic acids research
Yuan F,Jin X,Li D,Song Y,Zhang N,Yang X,Wang L,Zhu WG,Tian C,Zhao Y
Thu Sep 05 00:00:00 UTC 2019
SMCR8 negatively regulates AKT and MTORC1 signaling to modulate lysosome biogenesis and tissue homeostasis.
Autophagy
Lan Y,Sullivan PM,Hu F
Wed May 01 00:00:00 UTC 2019
Autophagy Regulates Craniofacial Bone Acquisition.
Calcified tissue international
Thomas N,Choi HK,Wei X,Wang L,Mishina Y,Guan JL,Liu F
Fri Nov 01 00:00:00 UTC 2019
Hyperosmotic Stress Induces Unconventional Autophagy Independent of the Ulk1 Complex.
Molecular and cellular biology
Tamura N,Kageyama S,Komatsu M,Waguri S
Thu Aug 15 00:00:00 UTC 2019
Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy.
Molecular cell
Vargas JNS,Wang C,Bunker E,Hao L,Maric D,Schiavo G,Randow F,Youle RJ
Thu Apr 18 00:00:00 UTC 2019
Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy.
Molecular cell
Vargas JNS,Wang C,Bunker E,Hao L,Maric D,Schiavo G,Randow F,Youle RJ
Thu Apr 18 00:00:00 UTC 2019
The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy.
Autophagy
Ho WY,Tai YK,Chang JC,Liang J,Tyan SH,Chen S,Guan JL,Zhou H,Shen HM,Koo E,Ling SC
Wed May 01 00:00:00 UTC 2019
Systematic analysis of ATG13 domain requirements for autophagy induction.
Autophagy
Wallot-Hieke N,Verma N,Schlütermann D,Berleth N,Deitersen J,Böhler P,Stuhldreier F,Wu W,Seggewiß S,Peter C,Gohlke H,Mizushima N,Stork B
Thu Oct 03 00:00:00 UTC 2019
Systematic analysis of ATG13 domain requirements for autophagy induction.
Autophagy
Wallot-Hieke N,Verma N,Schlütermann D,Berleth N,Deitersen J,Böhler P,Stuhldreier F,Wu W,Seggewiß S,Peter C,Gohlke H,Mizushima N,Stork B
Thu Oct 03 00:00:00 UTC 2019
Systematic analysis of ATG13 domain requirements for autophagy induction.
Autophagy
Wallot-Hieke N,Verma N,Schlütermann D,Berleth N,Deitersen J,Böhler P,Stuhldreier F,Wu W,Seggewiß S,Peter C,Gohlke H,Mizushima N,Stork B
Thu Oct 03 00:00:00 UTC 2019
Systematic analysis of ATG13 domain requirements for autophagy induction.
Autophagy
Wallot-Hieke N,Verma N,Schlütermann D,Berleth N,Deitersen J,Böhler P,Stuhldreier F,Wu W,Seggewiß S,Peter C,Gohlke H,Mizushima N,Stork B
Thu Oct 03 00:00:00 UTC 2019
Systematic analysis of ATG13 domain requirements for autophagy induction.
Autophagy
Wallot-Hieke N,Verma N,Schlütermann D,Berleth N,Deitersen J,Böhler P,Stuhldreier F,Wu W,Seggewiß S,Peter C,Gohlke H,Mizushima N,Stork B
Thu Oct 03 00:00:00 UTC 2019
Systematic analysis of ATG13 domain requirements for autophagy induction.
Autophagy
Wallot-Hieke N,Verma N,Schlütermann D,Berleth N,Deitersen J,Böhler P,Stuhldreier F,Wu W,Seggewiß S,Peter C,Gohlke H,Mizushima N,Stork B
Thu Oct 03 00:00:00 UTC 2019
The ER Contact Proteins VAPA/B Interact with Multiple Autophagy Proteins to Modulate Autophagosome Biogenesis.
Current biology : CB
Zhao YG,Liu N,Miao G,Chen Y,Zhao H,Zhang H
Mon Apr 23 00:00:00 UTC 2018
The ER Contact Proteins VAPA/B Interact with Multiple Autophagy Proteins to Modulate Autophagosome Biogenesis.
Current biology : CB
Zhao YG,Liu N,Miao G,Chen Y,Zhao H,Zhang H
Mon Apr 23 00:00:00 UTC 2018
The ER Contact Proteins VAPA/B Interact with Multiple Autophagy Proteins to Modulate Autophagosome Biogenesis.
Current biology : CB
Zhao YG,Liu N,Miao G,Chen Y,Zhao H,Zhang H
Mon Apr 23 00:00:00 UTC 2018
The ER Contact Proteins VAPA/B Interact with Multiple Autophagy Proteins to Modulate Autophagosome Biogenesis.
Current biology : CB
Zhao YG,Liu N,Miao G,Chen Y,Zhao H,Zhang H
Mon Apr 23 00:00:00 UTC 2018
Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation.
The Journal of cell biology
Morita K,Hama Y,Izume T,Tamura N,Ueno T,Yamashita Y,Sakamaki Y,Mimura K,Morishita H,Shihoya W,Nureki O,Mano H,Mizushima N
Mon Nov 05 00:00:00 UTC 2018
Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation.
The Journal of cell biology
Morita K,Hama Y,Izume T,Tamura N,Ueno T,Yamashita Y,Sakamaki Y,Mimura K,Morishita H,Shihoya W,Nureki O,Mano H,Mizushima N
Mon Nov 05 00:00:00 UTC 2018
Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17.
The Journal of cell biology
Matsui T,Jiang P,Nakano S,Sakamaki Y,Yamamoto H,Mizushima N
Mon Aug 06 00:00:00 UTC 2018
Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17.
The Journal of cell biology
Matsui T,Jiang P,Nakano S,Sakamaki Y,Yamamoto H,Mizushima N
Mon Aug 06 00:00:00 UTC 2018
Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy.
Nature communications
Wang C,Wang H,Zhang D,Luo W,Liu R,Xu D,Diao L,Liao L,Liu Z
Tue Aug 28 00:00:00 UTC 2018
Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy.
Nature communications
Wang C,Wang H,Zhang D,Luo W,Liu R,Xu D,Diao L,Liao L,Liu Z
Tue Aug 28 00:00:00 UTC 2018
RB1CC1-enhanced autophagy facilitates PSCs activation and pancreatic fibrogenesis in chronic pancreatitis.
Cell death & disease
Li L,Wang G,Hu JS,Zhang GQ,Chen HZ,Yuan Y,Li YL,Lv XJ,Tian FY,Pan SH,Bai XW,Sun B
Thu Sep 20 00:00:00 UTC 2018
RB1CC1-enhanced autophagy facilitates PSCs activation and pancreatic fibrogenesis in chronic pancreatitis.
Cell death & disease
Li L,Wang G,Hu JS,Zhang GQ,Chen HZ,Yuan Y,Li YL,Lv XJ,Tian FY,Pan SH,Bai XW,Sun B
Thu Sep 20 00:00:00 UTC 2018
Comparison of the expression of TGF-β1, E-cadherin, N-cadherin, TP53, RB1CC1 and HIF-1α in oral squamous cell carcinoma and lymph node metastases of humans and mice.
Oncology letters
Guo M,Mu Y,Yu D,Li J,Chen F,Wei B,Bi S,Yu J,Liang F
Thu Feb 01 00:00:00 UTC 2018
Galectin-8-mediated selective autophagy protects against seeded tau aggregation.
The Journal of biological chemistry
Falcon B,Noad J,McMahon H,Randow F,Goedert M
Fri Feb 16 00:00:00 UTC 2018
Galectin-8-mediated selective autophagy protects against seeded tau aggregation.
The Journal of biological chemistry
Falcon B,Noad J,McMahon H,Randow F,Goedert M
Fri Feb 16 00:00:00 UTC 2018
Global Reprogramming of Host Kinase Signaling in Response to Fungal Infection.
Cell host & microbe
Pandey A,Ding SL,Qin QM,Gupta R,Gomez G,Lin F,Feng X,Fachini da Costa L,Chaki SP,Katepalli M,Case ED,van Schaik EJ,Sidiq T,Khalaf O,Arenas A,Kobayashi KS,Samuel JE,Rivera GM,Alaniz RC,Sze SH,Qian X,Brown WJ,Rice-Ficht A,Russell WK,Ficht TA,de Figueiredo P
Wed May 10 00:00:00 UTC 2017
Global Reprogramming of Host Kinase Signaling in Response to Fungal Infection.
Cell host & microbe
Pandey A,Ding SL,Qin QM,Gupta R,Gomez G,Lin F,Feng X,Fachini da Costa L,Chaki SP,Katepalli M,Case ED,van Schaik EJ,Sidiq T,Khalaf O,Arenas A,Kobayashi KS,Samuel JE,Rivera GM,Alaniz RC,Sze SH,Qian X,Brown WJ,Rice-Ficht A,Russell WK,Ficht TA,de Figueiredo P
Wed May 10 00:00:00 UTC 2017
Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.
Nature immunology
Sasai M,Sakaguchi N,Ma JS,Nakamura S,Kawabata T,Bando H,Lee Y,Saitoh T,Akira S,Iwasaki A,Standley DM,Yoshimori T,Yamamoto M
Tue Aug 01 00:00:00 UTC 2017
Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.
Nature immunology
Sasai M,Sakaguchi N,Ma JS,Nakamura S,Kawabata T,Bando H,Lee Y,Saitoh T,Akira S,Iwasaki A,Standley DM,Yoshimori T,Yamamoto M
Tue Aug 01 00:00:00 UTC 2017
Autophagosome formation is initiated at phosphatidylinositol synthase-enriched ER subdomains.
The EMBO journal
Nishimura T,Tamura N,Kono N,Shimanaka Y,Arai H,Yamamoto H,Mizushima N
Wed Jun 14 00:00:00 UTC 2017
Autophagosome formation is initiated at phosphatidylinositol synthase-enriched ER subdomains.
The EMBO journal
Nishimura T,Tamura N,Kono N,Shimanaka Y,Arai H,Yamamoto H,Mizushima N
Wed Jun 14 00:00:00 UTC 2017
Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine.
Autophagy
Chen X,Clark J,Wunderlich M,Fan C,Davis A,Chen S,Guan JL,Mulloy JC,Kumar A,Zheng Y
Thu May 04 00:00:00 UTC 2017
Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine.
Autophagy
Chen X,Clark J,Wunderlich M,Fan C,Davis A,Chen S,Guan JL,Mulloy JC,Kumar A,Zheng Y
Thu May 04 00:00:00 UTC 2017
RUBCN/rubicon and EGFR regulate lysosomal degradative processes in the retinal pigment epithelium (RPE) of the eye.
Autophagy
Muniz-Feliciano L,Doggett TA,Zhou Z,Ferguson TA
Fri Jul 05 00:00:00 UTC 2019
RUBCN/rubicon and EGFR regulate lysosomal degradative processes in the retinal pigment epithelium (RPE) of the eye.
Autophagy
Muniz-Feliciano L,Doggett TA,Zhou Z,Ferguson TA
Fri Jul 05 00:00:00 UTC 2019
Remodeling of ER-exit sites initiates a membrane supply pathway for autophagosome biogenesis.
EMBO reports
Ge L,Zhang M,Kenny SJ,Liu D,Maeda M,Saito K,Mathur A,Xu K,Schekman R
Fri Sep 01 00:00:00 UTC 2017
Remodeling of ER-exit sites initiates a membrane supply pathway for autophagosome biogenesis.
EMBO reports
Ge L,Zhang M,Kenny SJ,Liu D,Maeda M,Saito K,Mathur A,Xu K,Schekman R
Fri Sep 01 00:00:00 UTC 2017
Remodeling of ER-exit sites initiates a membrane supply pathway for autophagosome biogenesis.
EMBO reports
Ge L,Zhang M,Kenny SJ,Liu D,Maeda M,Saito K,Mathur A,Xu K,Schekman R
Fri Sep 01 00:00:00 UTC 2017
Remodeling of ER-exit sites initiates a membrane supply pathway for autophagosome biogenesis.
EMBO reports
Ge L,Zhang M,Kenny SJ,Liu D,Maeda M,Saito K,Mathur A,Xu K,Schekman R
Fri Sep 01 00:00:00 UTC 2017
Differential requirement for ATG2A domains for localization to autophagic membranes and lipid droplets.
FEBS letters
Tamura N,Nishimura T,Sakamaki Y,Koyama-Honda I,Yamamoto H,Mizushima N
Fri Dec 01 00:00:00 UTC 2017
Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator.
eLife
Jung J,Nayak A,Schaeffer V,Starzetz T,Kirsch AK,Müller S,Dikic I,Mittelbronn M,Behrends C
Tue Feb 14 00:00:00 UTC 2017
Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator.
eLife
Jung J,Nayak A,Schaeffer V,Starzetz T,Kirsch AK,Müller S,Dikic I,Mittelbronn M,Behrends C
Tue Feb 14 00:00:00 UTC 2017
Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model.
Genes & development
Chen S,Wang C,Yeo S,Liang CC,Okamoto T,Sun S,Wen J,Guan JL
Fri Apr 01 00:00:00 UTC 2016
Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model.
Genes & development
Chen S,Wang C,Yeo S,Liang CC,Okamoto T,Sun S,Wen J,Guan JL
Fri Apr 01 00:00:00 UTC 2016
Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide.
The Journal of cell biology
Wang C,Chen S,Yeo S,Karsli-Uzunbas G,White E,Mizushima N,Virgin HW,Guan JL
Mon Feb 29 00:00:00 UTC 2016
Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide.
The Journal of cell biology
Wang C,Chen S,Yeo S,Karsli-Uzunbas G,White E,Mizushima N,Virgin HW,Guan JL
Mon Feb 29 00:00:00 UTC 2016
The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway.
Acta neuropathologica communications
Sullivan PM,Zhou X,Robins AM,Paushter DH,Kim D,Smolka MB,Hu F
Wed May 18 00:00:00 UTC 2016
The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway.
Acta neuropathologica communications
Sullivan PM,Zhou X,Robins AM,Paushter DH,Kim D,Smolka MB,Hu F
Wed May 18 00:00:00 UTC 2016
Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium.
Autophagy
Yao J,Jia L,Khan N,Lin C,Mitter SK,Boulton ME,Dunaief JL,Klionsky DJ,Guan JL,Thompson DA,Zacks DN
Fri Apr 22 00:00:00 UTC 2016
Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium.
Autophagy
Yao J,Jia L,Khan N,Lin C,Mitter SK,Boulton ME,Dunaief JL,Klionsky DJ,Guan JL,Thompson DA,Zacks DN
Fri Apr 22 00:00:00 UTC 2016
Macroautophagic cargo sequestration assays.
Methods (San Diego, Calif.)
Seglen PO,Luhr M,Mills IG,Sætre F,Szalai P,Engedal N
Sun Mar 01 00:00:00 UTC 2015
Macroautophagic cargo sequestration assays.
Methods (San Diego, Calif.)
Seglen PO,Luhr M,Mills IG,Sætre F,Szalai P,Engedal N
Sun Mar 01 00:00:00 UTC 2015
MiR224-3p inhibits hypoxia-induced autophagy by targeting autophagy-related genes in human glioblastoma cells.
Oncotarget
Guo X,Xue H,Guo X,Gao X,Xu S,Yan S,Han X,Li T,Shen J,Li G
Tue Dec 08 00:00:00 UTC 2015
MiR224-3p inhibits hypoxia-induced autophagy by targeting autophagy-related genes in human glioblastoma cells.
Oncotarget
Guo X,Xue H,Guo X,Gao X,Xu S,Yan S,Han X,Li T,Shen J,Li G
Tue Dec 08 00:00:00 UTC 2015
MiR224-3p inhibits hypoxia-induced autophagy by targeting autophagy-related genes in human glioblastoma cells.
Oncotarget
Guo X,Xue H,Guo X,Gao X,Xu S,Yan S,Han X,Li T,Shen J,Li G
Tue Dec 08 00:00:00 UTC 2015
MiR224-3p inhibits hypoxia-induced autophagy by targeting autophagy-related genes in human glioblastoma cells.
Oncotarget
Guo X,Xue H,Guo X,Gao X,Xu S,Yan S,Han X,Li T,Shen J,Li G
Tue Dec 08 00:00:00 UTC 2015
Imaging autophagy.
Current protocols in cytometry
Karanasios E,Stapleton E,Manifava M,Ktistakis NT
Tue Jul 01 00:00:00 UTC 2014
Imaging autophagy.
Current protocols in cytometry
Karanasios E,Stapleton E,Manifava M,Ktistakis NT
Tue Jul 01 00:00:00 UTC 2014
Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Liu F,Fang F,Yuan H,Yang D,Chen Y,Williams L,Goldstein SA,Krebsbach PH,Guan JL
Fri Nov 01 00:00:00 UTC 2013
Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Liu F,Fang F,Yuan H,Yang D,Chen Y,Williams L,Goldstein SA,Krebsbach PH,Guan JL
Fri Nov 01 00:00:00 UTC 2013