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Product Details
21269-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RB1CC1 Fusion Protein Ag15739 (1-350 aa encoded by BC017556)
Conjugate
Form
Liquid
Concentration
0.38 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is a rabbit polyclonal antibody raised against residues near the N terminus of human RB1CC1.
Immunogen sequence: MKLYVFLVN TGTTLTFDTE LTVQTVADLK HAIQSKYKIA IQHQVLVVNG GECMAADRRV CTYSAGTDTN PIFLFNKEMI LCDRPPAIPK TTFSTENDME IKVEESLMMP AVFHTVASRT QLALEMYEVA KKLCSFCEGL VHDEHLQHQG WAAIMANLED CSNSYQKLLF KFESIYSNYL QSIEDIKLKL THLGTAVSVM AKIPLLECLT RHSYRECLGR LDSLPEHEDS EKAETKRSTE LVLSPDMPRT TNESLLTSFP KSVEHVSPDT ADAESGKEIR ESCQSTVHQQ DETTIDTKDG DLPFFNVSLL DWINVQDRPN DVESLVRKCF DSMSRLDPRI IRPFIAECRQ T (1-350 aa encoded by BC017556)
Target Information
The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 200 kDa FAK family kinase-interacting protein; coiled coil forming protein 1; Coiled-coil-forming protein 1; FAK family kinase-interacting protein of 200 kDa; FIP200; LaXp180; phosphatase 1, regulatory subunit 131; RB1-inducible coiled-coil 1; RB1-inducible coiled-coil protein 1
Gene Aliases: 2900055E04Rik; 5930404L04Rik; ATG17; CC1; FIP200; KIAA0203; LaXp180; PPP1R131; RB1CC1; RBICC
UniProt ID: (Human) Q8TDY2, (Mouse) Q9ESK9
Entrez Gene ID: (Human) 9821, (Mouse) 12421, (Rat) 312927
autophagosome assembly
liver development
positive regulation of protein phosphorylation
transcription, DNA-templated
regulation of transcription, DNA-templated
autophagy
cell cycle
JNK cascade
heart development
regulation of autophagy
negative regulation of apoptotic process
positive regulation of cell size
negative regulation of extrinsic apoptotic signaling pathway
biological_process
macroautophagy
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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