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Bethyl Laboratories
RBL1 Polyclonal Antibody
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RBL1 Antibody (A305-672A-T) in IP
Detection of human RBL1 by western blot of immunoprecipitates. Samples: Whole cell lysate (1.0 mg per IP reaction; 10% of IP loaded) from Hep-G2 cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-RBL1 antibody (Product # A305-672A-T; lot 2) used for IP at 6 µg per reaction. RBL1 was also immunoprecipitated by a previous lot of this antibody (Product # A305-672A-T; lot 1) and a second antibody against a different epitope of RBL1 (BL22870). For blotting immunoprecipitated RBL1, Product # A305-672A-T was used at... View More
Product Details
A305-672A-T
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A region between residue 1018 to 1068 of human pRb1; Retinoblastoma-like protein 1; p107.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7.0 to 8.0
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Wet ice
Product Specific Information
Predicted reactivity by homology: Mouse.
Target Information
RB-like 1 is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and RB-like 1 can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that RB-like 1 may also be a tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 107 kDa retinoblastoma-associated protein; MGC40006; p107; pRb1; retinoblastoma-like 1; Retinoblastoma-like protein 1
Gene Aliases: CP107; p107; PRB1; RBL1
UniProt ID: (Human) P28749
Entrez Gene ID: (Human) 5933
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
cell cycle
negative regulation of gene expression
viral process
covalent chromatin modification
regulation of lipid kinase activity
positive regulation of transcription from RNA polymerase II promoter
regulation of cell cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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