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Invitrogen
RBM11 Polyclonal Antibody
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FIGURE: 1 / 1
RBM11 Antibody (PA5-89087) in WB
Western blot analysis of RBM11 in extracts of various cell lines. Samples were incubated with RBM11 Polyclonal antibody (Product # PA5-89087) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-89087
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-281 of human RBM11 (NP_6589833)
Conjugate
Form
Liquid
Concentration
1.58 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2805347
Product Specific Information
Immunogen sequence: MFPAQEEADR TVFVGNLEAR VREEILYELF LQAGPLTKVT ICKDREGKPK SFGFVCFKHP ESVSYAIALL NGIRLYGRPI NVQYRFGSSR SSEPANQSFE SCVKINSHNY RNEEMLVGRS SFPMQYFPIN NTSLPQEYFL FQKMQWHVYN PVLQLPYYEM TAPLPNSASV SSSLNHVPDL EAGPSSYKWT HQQPSDSDLY QMTAPLPNSA SVSSSLNHVP DLEAGPSSYK WTHQQPSDSD LYQMNKRKRQ KQTSDSDSST DNNRGNECSQ KFRKSKKKKR Y; Positive Samples: U-87MG, 293T, MCF7, Mouse testis, Rat testis; Cellular Location: Nucleus, Nucleus speckle, nucleoplasm
Target Information
The RBM11 (RNA Binding Motif Protein 11) gene encodes a protein that belongs to a family of RNA-binding proteins involved in the regulation of alternative splicing, a critical process for generating protein diversity. Located on chromosome 21q22.3, RBM11 contains RNA recognition motifs (RRMs) that facilitate its binding to RNA sequences, influencing splice site selection and exon inclusion or exclusion during pre-mRNA processing. RBM11 is expressed in various tissues, with notable expression in the nervous system, suggesting a role in neural development and function. Dysregulation of RBM11 has been associated with various diseases, including cancer, where it can impact the splicing of key regulatory genes involved in cell proliferation and apoptosis. Understanding the specific RNA targets and splicing events regulated by RBM11 can provide insights into its broader biological roles and its potential as a biomarker or therapeutic target in diseases characterized by aberrant splicing.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: putative RNA-binding protein 11; RNA-binding motif protein 11; Splicing regulator RBM11
Gene Aliases: A330018F01; RBM11
UniProt ID: (Human) P57052, (Mouse) Q80YT9
Entrez Gene ID: (Human) 54033, (Mouse) 224344, (Rat) 288321
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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