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Invitrogen
RBM15 Polyclonal Antibody
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RBM15 Antibody (PA5-99993) in IHC (P)
Immunohistochemistry analysis of RBM15 in mouse brain tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with RBM15 polyclonal antibody (Product # PA5-99993) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-99993
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human RBM15(Accession Q96T37), corresponding to amino acid residues M45-R95.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2818926
Product Specific Information
Antibody detects endogenous levels of total RBM15.
Target Information
May function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing. High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing. May be implicated in HOX gene regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: one twenty two protein; one twenty-two; One-twenty two protein 1; putative RNA-binding protein 15; RNA binding motif protein 15; RNA-binding motif protein 15; RNA-binding protein 15
Gene Aliases: C230088J01Rik; Kiaa4257; mKIAA1438; OTT; OTT1; RBM15; SPEN
UniProt ID: (Human) Q96T37, (Mouse) Q0VBL3
Entrez Gene ID: (Human) 64783, (Rat) 684233, (Mouse) 229700
mRNA splicing, via spliceosome
patterning of blood vessels
positive regulation of transcription of Notch receptor target
viral process
negative regulation of myeloid cell differentiation
negative regulation of transcription, DNA-templated
spleen development
ventricular septum morphogenesis
placenta blood vessel development
negative regulation of transcription from RNA polymerase II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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