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Product Details
PA5-53909
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RBM28. Recombinant protein control fragment (Product #RP-92674).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2646380
Product Specific Information
Immunogen sequence: RKLLLSATSG EKGVRIKECR VMRDLKGVHG NMKGQSLGYA FAEFQEHEHA LKALRLINNN PEIFGPLKRP IVEFSLEDRR KLKMKELRIQ RSLQKMRSKP ATGEPQKGQP EPAKDQQQK
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 82%.
Target Information
Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3. Also binds 25-hydroxycholesterol and cholesterol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2810480G15Rik; RNA-binding motif protein 28; RNA-binding protein 28
Gene Aliases: ANES; RBM28
UniProt ID: (Human) Q9NW13
Entrez Gene ID: (Human) 55131
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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