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Product Details
MA5-46552
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Xenopus
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
4C4
Immunogen
Human full length native protein (purified)
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2937624
Product Specific Information
Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Western blot detects a band of approximately 21 kDa (predicted molecular weight: 21 kDa).
Target Information
This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. Two alternative start codons result in two forms of the protein, and this gene also uses multiple polyadenylation sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Binder of OVCA1-1; BOV-1; BOV1; BOV1A; BOV1B; BOV1C; ribonucleoprotein RBM8; Ribonucleoprotein RBM8A; Ribonucleoprotein RBM8A-A; RNA binding motif protein 8B; rna-binding; RNA-binding motif protein 8A; RNA-binding motif protein 8A-A; RNA-binding protein 8A; RNA-binding protein 8A-A; RNA-binding protein Y14
Gene Aliases: BOV-1A; BOV-1B; BOV-1C; C1DELq21.1; DEL1q21.1; HSPC114; MDS014; RBM8; rbm8-A; RBM8A; rbm8a-A; rbm8a-b; RBM8B; TAR; tsunagi; XELAEV_18042903mg; Y14; ZNRP; ZRNP1
UniProt ID: (Human) Q9Y5S9, (Xenopus) Q9DF42
Entrez Gene ID: (Human) 9939, (Xenopus) 399167
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
regulation of alternative mRNA splicing, via spliceosome
mRNA splicing, via spliceosome
termination of RNA polymerase II transcription
RNA export from nucleus
mRNA export from nucleus
regulation of translation
mRNA 3'-end processing
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