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Product Details
MA1-35782
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Goat,
Human,
Mouse,
Non-human primate,
Rabbit,
Rat
Published species
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
G4E4
Immunogen
Human retinol binding protein (RBP) purified from plasma
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
purified
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2179286
Product Specific Information
G4E4 recognizes an epitope within the 74-182 C-terminal sequence (11kD peptide fragment) of human serum Cellular Retinol Binding Protein 1 (CRBP 1), a single-chain glycoprotein belonging to the superfamily of hydrophobic molecule transporter proteins, which is responsible for transport of retinol (vitamin A1) from the liver to peripheral target tissues, like the eye, where it mediates the cellular uptake. CRBP 1 is synthesized by hepatic parenchymal cells where it becomes bound to its ligand retinol and is then released into the circulation, where it binds further to the protein transthyretin, to form a transporting complex, which is big enough not to be lost by filtration through the kidney glomeruli. It is detected in nearly all tissues with higher expression in adult ovary, pancreas, pituitary gland, adrenal gland, and fetal liver.
Target Information
This gene encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C CRABP-I; cellular retinol binding protein 1; Cellular retinol-binding protein; Cellular retinol-binding protein I; CRBP; CRBP-I; mCRBPI; RBP; retinol; retinol binding; Retinol Binding Protein; retinol binding protein 1, cellular-like; Retinol-binding protein 1; retinol-binding protein 1, cellular
Gene Aliases: CRABP-I; CRBP; CRBP1; CRBPI; Rbp-1; RBP1; RBPC
UniProt ID: (Human) P09455, (Mouse) Q00915, (Rat) P02696
Entrez Gene ID: (Rabbit) 100354448, (Human) 5947, (Mouse) 19659, (Rat) 25056
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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