Invitrogen

RBPJ Monoclonal Antibody (6G4)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-49168

Applications
Tested Dilution
Publications

Western Blot (WB)

0.25-0.5 µg/mL
-

Flow Cytometry (Flow)

1-3 µg/1x10^6 cells
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

6G4

Immunogen

E.coli-derived human RBPJK/RBPJ recombinant protein (Position: K41-Q467).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3074826

Product Specific Information

Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.

Positive Control - WB: human HEK293 whole cell, human HEPG2 whole cell, human HELA whole cell, human MCF-7 whole cell, human U87 whole cell, human HL-60 whole cell, rat NRK whole cell, mouse smooth muscle tissue. Flow: HEPA1-6 cell, U937 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Information

CSL plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. The protein is abundantly expressed in heart and skeletal muscle and expression is increased by passive stretch. Mutations in this gene can lead to X-linked deafness.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CBF-1; H-2K binding factor-2; immunoglobulin kappa J region recombination signal binding protein 1; J kappa-recombination signal-binding protein; RBP-J; RBP-J kappa; RBP-JK; rbp-jkappa; Recombining binding protein suppressor of hairless; Renal carcinoma antigen NY-REN-30; suppressor of hairless homolog

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Gene Aliases: AI843960; AOS3; CBF1; csl; IGKJRB; IGKJRB1; Igkrsbp; KBF2; RBP-J; RBP-J kappa; RBPJ; RBPJK; RBPSUH; SUH

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UniProt ID: (Human) Q06330, (Mouse) P31266

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Entrez Gene ID: (Human) 3516, (Mouse) 19664, (Rat) 679028

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Function(s)
recombinase activity RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II repressing transcription factor binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding sequence-specific DNA binding protein N-terminus binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding protein complex binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter angiogenesis somitogenesis epithelial to mesenchymal transition heart looping blood vessel remodeling inflammatory response to antigenic stimulus secondary heart field specification outflow tract morphogenesis endocardium development endocardium morphogenesis epithelial to mesenchymal transition involved in endocardial cushion formation cardiac left ventricle morphogenesis ventricular trabecula myocardium morphogenesis regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter humoral immune response Notch signaling pathway positive regulation of transcription of Notch receptor target heart development positive regulation of cell proliferation negative regulation of cell proliferation auditory receptor cell fate commitment epidermal cell fate specification regulation of gene expression positive regulation of gene expression negative regulation of neuron projection development negative regulation of smooth muscle cell migration pituitary gland development hemopoiesis neuron differentiation B cell differentiation keratinocyte differentiation negative regulation of ossification positive regulation of BMP signaling pathway negative regulation of smooth muscle cell apoptotic process somatic stem cell population maintenance positive regulation of Notch signaling pathway involved in heart induction dorsal aorta morphogenesis atrioventricular canal development defense response to bacterium myeloid dendritic cell differentiation cell fate commitment negative regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of timing of cell differentiation positive regulation of smooth muscle cell proliferation sebaceous gland development hair follicle maturation artery morphogenesis positive regulation of cardiac muscle cell proliferation Clara cell differentiation labyrinthine layer blood vessel development arterial endothelial cell fate commitment Notch signaling pathway involved in arterial endothelial cell fate commitment regulation of cell adhesion involved in heart morphogenesis determination of heart left/right asymmetry positive regulation of transcription from RNA polymerase II promoter in response to hypoxia blood vessel lumenization interleukin-4 secretion blood vessel endothelial cell fate specification positive regulation of ERBB signaling pathway positive regulation of ephrin receptor signaling pathway positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment positive regulation of cell proliferation involved in heart morphogenesis DNA recombination transcription initiation from RNA polymerase II promoter Notch signaling involved in heart development
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