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Product Details
CF810470
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI10C6
Immunogen
Full length human recombinant protein of human RCAN1 produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
The RCAN1 protein interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adapt78; calcineurin inhibitor; Calcipressin-1; calcium and oxidant-inducible mRNA; Down syndrome candidate region 1; Down syndrome critical region gene 1; Down syndrome critical region protein 1; Down syndrome critical region protein 1 homolog; MCIP1; modulatory calcineurin-interacting protein 1; Myocyte-enriched calcineurin-interacting protein 1; near DSCR proline-rich protein; Regulator of calcineurin 1
Gene Aliases: ADAPT78; CALP1L; CSP1; DSC1; DSCR1; MCIP1; RCAN1; RCN1
UniProt ID: (Human) P53805, (Mouse) Q9JHG6
Entrez Gene ID: (Human) 1827, (Mouse) 54720
response to ischemia
response to stress
response to oxidative stress
short-term memory
calcium-mediated signaling
locomotion involved in locomotory behavior
calcineurin-NFAT signaling cascade
regulation of phosphoprotein phosphatase activity
skeletal muscle fiber development
regulation of catalytic activity
regulation of calcineurin-NFAT signaling cascade
regulation of transcription, DNA-templated
signal transduction
central nervous system development
blood circulation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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