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Invitrogen
RCCD1 Polyclonal Antibody
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FIGURE: 1 / 1
RCCD1 Antibody (PA5-110283) in WB
Western blot analysis of RCCD1 in extracts of THP-1 cells. Samples were incubated with RCCD1 Polyclonal antibody (Product # PA5-110283) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-110283
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 230-360 of human RCCD1 (NP_001017919.1).
Conjugate
Form
Liquid
Concentration
3.14 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2855694
Product Specific Information
Immunogen sequence: DIYIWGWNES GQLALPTRNL AEDGETVARE ATELNEDGSQ VKRTGGAEDG APAPFIAVQP FPALLDLPMG SDAVKASCGS RHTAVVTRTG ELYTWGWGKY GQLGHEDTTS LDRPRRVEYF VDKQLQVKAV T
Target Information
Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8 (PubMed:24981860). Possibly together with KDM8, is involved in proper mitotic spindle organization and chromosome segregation (PubMed:24981860). Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability, thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8 (PubMed:28455245).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: RCC1 domain containing 1; RCC1 domain-containing protein 1
Gene Aliases: RCCD1; RGD1309901
UniProt ID: (Human) A6NED2
Entrez Gene ID: (Human) 91433, (Rat) 308760
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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