Proteintech

RCN2 Polyclonal Antibody

RCN2 Antibody in Immunocytochemistry (ICC/IF)

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RCN2 Antibody (10193-2-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using RCN2 antibody 10193-2-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IGG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

RCN2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

RCN2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10193-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RCN2 Fusion Protein Ag0247 (23-209 aa encoded by BC004892)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: GKAEELHYP LGERRSDYDR EALLGVQEDV DEYVKLGHEE QQKRLQAIIK KIDLDSDGFL TESELSSWIQ MSFKHYAMQE AKQQFVEYDK NSDDTVTWDE YNIQMYDRVI DFDENTALDD AEEESFRKLH LKDKKRFEKA NQDSGPGLSL EEFIAFEHPE EVDYMTEFVI QEALEEHDKN GDGFVSLE (23-209 aa encoded by BC004892 )

Target Information

The protein encoded by this gene is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. This gene maps to the same region as type 4 Bardet-Biedl syndrome, suggesting a possible causative role for this gene in the disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

RCN2 promotes Nasopharyngeal carcinoma progression by curbing Calcium flow and Mitochondrial apoptosis.

Cellular oncology (Dordrecht, Netherlands)

Yao H,Zhang S,Xie H,Fan Y,Miao M,Zhu R,Yuan L,Gu M,You Y,You B

Tue Aug 01 00:00:00 UTC 2023

RCN2 promotes Nasopharyngeal carcinoma progression by curbing Calcium flow and Mitochondrial apoptosis.

Cellular oncology (Dordrecht, Netherlands)

Yao H,Zhang S,Xie H,Fan Y,Miao M,Zhu R,Yuan L,Gu M,You Y,You B

Tue Aug 01 00:00:00 UTC 2023

RCN2 promotes Nasopharyngeal carcinoma progression by curbing Calcium flow and Mitochondrial apoptosis.

Cellular oncology (Dordrecht, Netherlands)

Yao H,Zhang S,Xie H,Fan Y,Miao M,Zhu R,Yuan L,Gu M,You Y,You B

Tue Aug 01 00:00:00 UTC 2023

Reticulocalbin 2 as a Potential Biomarker and Therapeutic Target for Atherosclerosis.

Cells

Li J,Taylor AM,Manichaikul A,Angle JF,Shi W

Fri Mar 25 00:00:00 UTC 2022

A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis.

Cell metabolism

Peng H,Hu B,Xie LQ,Su T,Li CJ,Liu Y,Yang M,Xiao Y,Feng X,Zhou R,Guo Q,Zhou HY,Huang Y,Jiang TJ,Luo XH

Tue Aug 02 00:00:00 UTC 2022

YY1-mediated reticulocalbin-2 upregulation promotes the hepatocellular carcinoma progression via activating MYC signaling.

American journal of cancer research

Mei C,Jiang X,Gu Y,Wu X,Ma W,Chen X,Wang G,Yao Y,Liu Y,Zhang Z,Yuan Y

Tue Jun 08 00:00:00 UTC 2021

Loss of reticulocalbin 2 lowers blood pressure and restrains ANG II-induced hypertension in vivo.

American journal of physiology. Renal physiology

Li J,Cechova S,Wang L,Isakson BE,Le TH,Shi W

Sat Jun 01 00:00:00 UTC 2019

Loss of reticulocalbin 2 lowers blood pressure and restrains ANG II-induced hypertension in vivo.

American journal of physiology. Renal physiology

Li J,Cechova S,Wang L,Isakson BE,Le TH,Shi W

Sat Jun 01 00:00:00 UTC 2019

Reticulocalbin 2 correlates with recurrence and prognosis in colorectal cancer.

American journal of cancer research

Wang G,Wang Q,Fan Y,He X

Thu Oct 01 00:00:00 UTC 2020

Reticulocalbin 2 correlates with recurrence and prognosis in colorectal cancer.

American journal of cancer research

Wang G,Wang Q,Fan Y,He X

Thu Oct 01 00:00:00 UTC 2020

Reticulocalbin 2 correlates with recurrence and prognosis in colorectal cancer.

American journal of cancer research

Wang G,Wang Q,Fan Y,He X

Thu Oct 01 00:00:00 UTC 2020

Reticulocalbin 2 correlates with recurrence and prognosis in colorectal cancer.

American journal of cancer research

Wang G,Wang Q,Fan Y,He X

Thu Oct 01 00:00:00 UTC 2020

Proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylation.

eLife

Hung V,Lam SS,Udeshi ND,Svinkina T,Guzman G,Mootha VK,Carr SA,Ting AY

Tue Apr 25 00:00:00 UTC 2017

Proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylation.

eLife

Hung V,Lam SS,Udeshi ND,Svinkina T,Guzman G,Mootha VK,Carr SA,Ting AY

Tue Apr 25 00:00:00 UTC 2017

Live-cell mapping of organelle-associated RNAs via proximity biotinylation combined with protein-RNA crosslinking.

eLife

Kaewsapsak P,Shechner DM,Mallard W,Rinn JL,Ting AY

Thu Dec 14 00:00:00 UTC 2017

Live-cell mapping of organelle-associated RNAs via proximity biotinylation combined with protein-RNA crosslinking.

eLife

Kaewsapsak P,Shechner DM,Mallard W,Rinn JL,Ting AY

Thu Dec 14 00:00:00 UTC 2017

Phosphatidylinositol glycan anchor biosynthesis, class X containing complex promotes cancer cell proliferation through suppression of EHD2 and ZIC1, putative tumor suppressors.

International journal of oncology

Nakakido M,Tamura K,Chung S,Ueda K,Fujii R,Kiyotani K,Nakamura Y

Thu Sep 01 00:00:00 UTC 2016

Phosphatidylinositol glycan anchor biosynthesis, class X containing complex promotes cancer cell proliferation through suppression of EHD2 and ZIC1, putative tumor suppressors.

International journal of oncology

Nakakido M,Tamura K,Chung S,Ueda K,Fujii R,Kiyotani K,Nakamura Y

Thu Sep 01 00:00:00 UTC 2016

Phosphatidylinositol glycan anchor biosynthesis, class X containing complex promotes cancer cell proliferation through suppression of EHD2 and ZIC1, putative tumor suppressors.

International journal of oncology

Nakakido M,Tamura K,Chung S,Ueda K,Fujii R,Kiyotani K,Nakamura Y

Thu Sep 01 00:00:00 UTC 2016

Phosphatidylinositol glycan anchor biosynthesis, class X containing complex promotes cancer cell proliferation through suppression of EHD2 and ZIC1, putative tumor suppressors.

International journal of oncology

Nakakido M,Tamura K,Chung S,Ueda K,Fujii R,Kiyotani K,Nakamura Y

Thu Sep 01 00:00:00 UTC 2016

Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy.

Nature medicine

Yokoi N,Fukata Y,Kase D,Miyazaki T,Jaegle M,Ohkawa T,Takahashi N,Iwanari H,Mochizuki Y,Hamakubo T,Imoto K,Meijer D,Watanabe M,Fukata M

Thu Jan 01 00:00:00 UTC 2015

Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy.

Nature medicine

Yokoi N,Fukata Y,Kase D,Miyazaki T,Jaegle M,Ohkawa T,Takahashi N,Iwanari H,Mochizuki Y,Hamakubo T,Imoto K,Meijer D,Watanabe M,Fukata M

Thu Jan 01 00:00:00 UTC 2015

Characterization of Ath29, a major mouse atherosclerosis susceptibility locus, and identification of Rcn2 as a novel regulator of cytokine expression.

American journal of physiology. Heart and circulatory physiology

Manichaikul A,Wang Q,Shi YL,Zhang Z,Leitinger N,Shi W

Thu Sep 01 00:00:00 UTC 2011

Characterization of Ath29, a major mouse atherosclerosis susceptibility locus, and identification of Rcn2 as a novel regulator of cytokine expression.

American journal of physiology. Heart and circulatory physiology

Manichaikul A,Wang Q,Shi YL,Zhang Z,Leitinger N,Shi W

Thu Sep 01 00:00:00 UTC 2011

Characterization of Ath29, a major mouse atherosclerosis susceptibility locus, and identification of Rcn2 as a novel regulator of cytokine expression.

American journal of physiology. Heart and circulatory physiology

Manichaikul A,Wang Q,Shi YL,Zhang Z,Leitinger N,Shi W

Thu Sep 01 00:00:00 UTC 2011

Characterization of Ath29, a major mouse atherosclerosis susceptibility locus, and identification of Rcn2 as a novel regulator of cytokine expression.

American journal of physiology. Heart and circulatory physiology

Manichaikul A,Wang Q,Shi YL,Zhang Z,Leitinger N,Shi W

Thu Sep 01 00:00:00 UTC 2011

Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation.

Proceedings of the National Academy of Sciences of the United States of America

Li L,Sun L,Gao F,Jiang J,Yang Y,Li C,Gu J,Wei Z,Yang A,Lu R,Ma Y,Tang F,Kwon SW,Zhao Y,Li J,Jin Y

Tue Jan 26 00:00:00 UTC 2010

Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation.

Proceedings of the National Academy of Sciences of the United States of America

Li L,Sun L,Gao F,Jiang J,Yang Y,Li C,Gu J,Wei Z,Yang A,Lu R,Ma Y,Tang F,Kwon SW,Zhao Y,Li J,Jin Y

Tue Jan 26 00:00:00 UTC 2010

Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation.

Proceedings of the National Academy of Sciences of the United States of America

Li L,Sun L,Gao F,Jiang J,Yang Y,Li C,Gu J,Wei Z,Yang A,Lu R,Ma Y,Tang F,Kwon SW,Zhao Y,Li J,Jin Y

Tue Jan 26 00:00:00 UTC 2010

Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation.

Proceedings of the National Academy of Sciences of the United States of America

Li L,Sun L,Gao F,Jiang J,Yang Y,Li C,Gu J,Wei Z,Yang A,Lu R,Ma Y,Tang F,Kwon SW,Zhao Y,Li J,Jin Y

Tue Jan 26 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: Calcium-binding protein ERC-55; E6-binding protein; E6BP; reticulocalbin 2, EF-hand calcium binding domain (endoplasmic reticulum calcium-binding protein, 55kD); Reticulocalbin-2; taipoxin-associated calcium binding protein 49; Taipoxin-associated calcium-binding protein 49; TCBP-49

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Gene Aliases: AA408742; E6BP; ERC-55; ERC55; RCN2; TCBP49

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UniProt ID: (Human) Q14257, (Mouse) Q8BP92, (Rat) Q62703

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Entrez Gene ID: (Human) 5955, (Mouse) 26611, (Rat) 29218

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Function(s)

calcium ion binding protein binding metal ion binding

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RCN2 Polyclonal Antibody

RCN2 Antibody (10193-2-AP) in ICC/IF

Product Details

10193-2-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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