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RCN3 Antibody (PA5-98793) in IHC (P)
Immunohistochemical analysis of RCN3 in paraffin embedded human adrenal gland tissue using a RCN3 polyclonal antibody (Product # PA5-98793) at a dilution of 1:200. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is ... View More
Product Details
PA5-98793
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Reticulocalbin-3 protein (71-161AA)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2813406
Target Information
Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (PubMed:16433634, PubMed:28939891). Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (PubMed:28939891). This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (PubMed:16433634). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EF-hand calcium-binding protein RLP49; reticulocabin; reticulocalbin 3, EF-hand calcium binding domain; Reticulocalbin-3
Gene Aliases: 6030455P07Rik; D530026G20Rik; D7Ertd671e; RCN3; RLP49; UNQ239/PRO272
UniProt ID: (Human) Q96D15, (Mouse) Q8BH97
Entrez Gene ID: (Human) 57333, (Mouse) 52377
Performance Guarantee
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