Proteintech

RDH12 Polyclonal Antibody

View all (6) RDH12 antibodies

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

13289-3-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RDH12 Fusion Protein Ag3850 (1-316 aa encoded by BC025724)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MLVTLGLLT SFFSFLYMVA PSIRKFFAGG VCRTNVQLPG KVVVITGANT GIGKETAREL ASRGARVYIA CRDVLKGESA ASEIRVDTKN SQVLVRKLDL SDTKSIRAFA EGFLAEEKQL HILINNAGVM MCPYSKTADG FETHLGVNHL GHFLLTYLLL EQLKVSAPAR VVNVSSVAHH IGKIPFHDLQ SEKRYSRGFA YCHSKLANVL FTRELAKRLQ GTGVTTYAVH PGVVRSELVR HSSLLCLLWR LFSPFVKTAR EGAQTSLHCA LAEGLEPLSG KYFSDCKRTW VSPRARNNKT AERLWNVSCE LLGIRWE (1-316 aa encoded by BC025724)

Target Information

The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 3 (LCA3).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: All-trans and 9-cis retinol dehydrogenase; LCA3; Retinol dehydrogenase 12; retinol dehydrogenase 12, all-trans and 9-cis; Short chain dehydrogenase/reductase family 7C member 2; short chain dehydrogenase/reductase family 7C, member 2

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Gene Aliases: A930033N07Rik; LCA13; RDH12; RP53; SDR7C2

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UniProt ID: (Human) Q96NR8, (Mouse) Q8BYK4

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Entrez Gene ID: (Human) 145226, (Rat) 314264, (Mouse) 77974

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Function(s)
retinol dehydrogenase activity protein binding NADP-retinol dehydrogenase activity molecular_function C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity aldo-keto reductase (NADP) activity isocitrate dehydrogenase activity mevaldate reductase activity gluconate dehydrogenase activity steroid dehydrogenase activity oxidoreductase activity epoxide dehydrogenase activity 5-exo-hydroxycamphor dehydrogenase activity 2-hydroxytetrahydrofuran dehydrogenase activity acetoin dehydrogenase activity phenylcoumaran benzylic ether reductase activity D-xylose:NADP reductase activity L-arabinose:NADP reductase activity D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor steroid dehydrogenase activity, acting on the CH-CH group of donors (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity 3-hydroxymenthone dehydrogenase activity very long-chain-3-hydroxyacyl-CoA dehydrogenase activity dihydrotestosterone 17-beta-dehydrogenase activity (R)-2-hydroxyisocaproate dehydrogenase activity L-arabinose 1-dehydrogenase (NADP+) activity L-xylulose reductase (NAD+) activity 3-ketoglucose-reductase activity (R)-2-hydroxyglutarate dehydrogenase activity D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity
Process(es)
retinoid metabolic process visual perception retinol metabolic process photoreceptor cell maintenance response to stimulus oxidation-reduction process biological_process metabolic process
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