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This target displays homology in the following species: Dog: 93%; Human: 100%; Pig: 79%; Rat: 79%
The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 3 (LCA3).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: All-trans and 9-cis retinol dehydrogenase; LCA3; Retinol dehydrogenase 12; retinol dehydrogenase 12, all-trans and 9-cis; Short chain dehydrogenase/reductase family 7C member 2; short chain dehydrogenase/reductase family 7C, member 2
Gene Aliases: LCA13; RDH12; RP53; SDR7C2
UniProt ID: (Human) Q96NR8
Entrez Gene ID: (Human) 145226
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