Proteintech

REC8 Polyclonal Antibody

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REC8 Antibody (10793-1-AP) in WB

Human testis tissue were subjected to SDS PAGE followed by western blot with 10793-1-AP (REC8 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Product Details

10793-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

Assay-dependent

View 7 publications 7 publications

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

REC8 Fusion Protein Ag1250 (188-548 aa encoded by BC010887)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human REC8. This antibody can recognize the monomeric, non-phosphorylated form (63-70 kDa) of REC8 and other forms(80-100 kDa) which represent either post translationally modified forms or alternative transcript products.

Immunogen sequence: VLPPEAITI LEAEPIRMLE IEGERELPEV SRRELDLLIA EEEEAILLEI PRLPPPAPAE VEGIGEALGP EELRLTGWEP GALLMEVTPP EELRLPAPPS PERRPPVPPP PRRRRRRRLL FWDKETQISP EKFQEQLQTR AHCWECPMVQ PPERTIRGPA ELFRTPTLSG WLPPELLGLW THCAQPPPKA LRRELPEEAA AEEERRKIEV PSEIEVPREA LEPSVPLMVS LEISLEAAEE EKSRISLIPP EERWAWPEVE APEAPALPVV PELPEVPMEM PLVLPPELEL LSLEAVHRAV ALELQANREP DFSSLVSPLS PRRMAARVFY LLLVLSAQQI LHVKQEKPYG RLLIQPGPRF H (188-548 aa encoded by BC010887)

Target Information

This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Ephedra herb reduces adriamycin-induced testicular toxicity by upregulating the gonadotropin-releasing hormone signalling pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Fu Y,Yuan P,Zheng Y,Gao L,Wei Y,Chen Y,Li P,Ruan Y,Zheng X,Feng W

Wed Jun 01 00:00:00 UTC 2022

Knockout of cyclin B1 in granulosa cells causes female subfertility.

Cell cycle (Georgetown, Tex.)

Cheng J,Liu Y

Thu Sep 01 00:00:00 UTC 2022

CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I.

Nature communications

Zhou CJ,Wang XY,Dong YH,Wang DH,Han Z,Zhang XJ,Sun QY,Carroll J,Liang CG

Tue Dec 13 00:00:00 UTC 2022

"Mitotic Slippage" and Extranuclear DNA in Cancer Chemoresistance: A Focus on Telomeres.

International journal of molecular sciences

Salmina K,Bojko A,Inashkina I,Staniak K,Dudkowska M,Podlesniy P,Rumnieks F,Vainshelbaum NM,Pjanova D,Sikora E,Erenpreisa J

Thu Apr 16 00:00:00 UTC 2020

REC8 suppresses tumor angiogenesis by inhibition of NF-κB-mediated vascular endothelial growth factor expression in gastric cancer cells.

Biological research

Liu M,Xu W,Su M,Fan P

Mon Sep 21 00:00:00 UTC 2020

In-Frame Variants in STAG3 Gene Cause Premature Ovarian Insufficiency.

Frontiers in genetics

Xiao WJ,He WB,Zhang YX,Meng LL,Lu GX,Lin G,Tan YQ,Du J

Mon Sep 28 00:00:00 UTC 2020

A study of meiomitosis and novel pathways of genomic instability in cutaneous T-cell lymphomas (CTCL).

Oncotarget

Tsang M,Gantchev J,Netchiporouk E,Moreau L,Ghazawi FM,Glassman S,Sasseville D,Litvinov IV

Fri Dec 28 00:00:00 UTC 2018

A study of meiomitosis and novel pathways of genomic instability in cutaneous T-cell lymphomas (CTCL).

Oncotarget

Tsang M,Gantchev J,Netchiporouk E,Moreau L,Ghazawi FM,Glassman S,Sasseville D,Litvinov IV

Fri Dec 28 00:00:00 UTC 2018

Merotelic kinetochore attachment in oocyte meiosis II causes sister chromatids segregation errors in aged mice.

Cell cycle (Georgetown, Tex.)

Cheng JM,Li J,Tang JX,Hao XX,Wang ZP,Sun TC,Wang XX,Zhang Y,Chen SR,Liu YX

Thu Aug 03 00:00:00 UTC 2017

Merotelic kinetochore attachment in oocyte meiosis II causes sister chromatids segregation errors in aged mice.

Cell cycle (Georgetown, Tex.)

Cheng JM,Li J,Tang JX,Hao XX,Wang ZP,Sun TC,Wang XX,Zhang Y,Chen SR,Liu YX

Thu Aug 03 00:00:00 UTC 2017

Elevated intracellular pH appears in aged oocytes and causes oocyte aneuploidy associated with the loss of cohesion in mice.

Cell cycle (Georgetown, Tex.)

Cheng JM,Li J,Tang JX,Chen SR,Deng SL,Jin C,Zhang Y,Wang XX,Zhou CX,Liu YX

Fri Sep 16 00:00:00 UTC 2016

Elevated intracellular pH appears in aged oocytes and causes oocyte aneuploidy associated with the loss of cohesion in mice.

Cell cycle (Georgetown, Tex.)

Cheng JM,Li J,Tang JX,Chen SR,Deng SL,Jin C,Zhang Y,Wang XX,Zhou CX,Liu YX

Fri Sep 16 00:00:00 UTC 2016

Ectopic expression of cancer-testis antigens in cutaneous T-cell lymphoma patients.

Clinical cancer research : an official journal of the American Association for Cancer Research

Litvinov IV,Cordeiro B,Huang Y,Zargham H,Pehr K,Doré MA,Gilbert M,Zhou Y,Kupper TS,Sasseville D

Tue Jul 15 00:00:00 UTC 2014

Ectopic expression of cancer-testis antigens in cutaneous T-cell lymphoma patients.

Clinical cancer research : an official journal of the American Association for Cancer Research

Litvinov IV,Cordeiro B,Huang Y,Zargham H,Pehr K,Doré MA,Gilbert M,Zhou Y,Kupper TS,Sasseville D

Tue Jul 15 00:00:00 UTC 2014

SUMO-1 plays crucial roles for spindle organization, chromosome congression, and chromosome segregation during mouse oocyte meiotic maturation.

Molecular reproduction and development

Yuan YF,Zhai R,Liu XM,Khan HA,Zhen YH,Huo LJ

Fri Aug 01 00:00:00 UTC 2014

SUMO-1 plays crucial roles for spindle organization, chromosome congression, and chromosome segregation during mouse oocyte meiotic maturation.

Molecular reproduction and development

Yuan YF,Zhai R,Liu XM,Khan HA,Zhen YH,Huo LJ

Fri Aug 01 00:00:00 UTC 2014

SUMO-1 plays crucial roles for spindle organization, chromosome congression, and chromosome segregation during mouse oocyte meiotic maturation.

Molecular reproduction and development

Yuan YF,Zhai R,Liu XM,Khan HA,Zhen YH,Huo LJ

Fri Aug 01 00:00:00 UTC 2014

SUMO-1 plays crucial roles for spindle organization, chromosome congression, and chromosome segregation during mouse oocyte meiotic maturation.

Molecular reproduction and development

Yuan YF,Zhai R,Liu XM,Khan HA,Zhen YH,Huo LJ

Fri Aug 01 00:00:00 UTC 2014

Germ cell proteins in melanoma: prognosis, diagnosis, treatment, and theories on expression.

Journal of skin cancer

Rosa AM,Dabas N,Byrnes DM,Eller MS,Grichnik JM

Wed Dec 05 00:00:00 UTC 2012

Germ cell proteins in melanoma: prognosis, diagnosis, treatment, and theories on expression.

Journal of skin cancer

Rosa AM,Dabas N,Byrnes DM,Eller MS,Grichnik JM

Wed Dec 05 00:00:00 UTC 2012

The role of meiotic cohesin REC8 in chromosome segregation in gamma irradiation-induced endopolyploid tumour cells.

Experimental cell research

Erenpreisa J,Cragg MS,Salmina K,Hausmann M,Scherthan H

Thu Sep 10 00:00:00 UTC 2009

The role of meiotic cohesin REC8 in chromosome segregation in gamma irradiation-induced endopolyploid tumour cells.

Experimental cell research

Erenpreisa J,Cragg MS,Salmina K,Hausmann M,Scherthan H

Thu Sep 10 00:00:00 UTC 2009

Bioinformatics

Protein Aliases: Cohesin Rec8p; cohesion rec8p; human homolog of rad21, S. pombe; kleisin-alpha; meiotic cohesion Rec8; meiotic recombination and sister chromatid cohesion phosphoprotein of the rad21p family; Meiotic recombination protein REC8 homolog; meiotic recombination protein REC8-like 1; REC8 homolog; REC8-like 1; recombination and sister chromatid cohesion protein homolog

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Gene Aliases: HR21spB; Mei8; mrec; REC8; REC8L1; Rec8p

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UniProt ID: (Human) O95072, (Mouse) Q8C5S7

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Entrez Gene ID: (Human) 9985, (Mouse) 56739

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Function(s)

protein binding

Process(es)

double-strand break repair via homologous recombination oocyte maturation sister chromatid cohesion meiotic nuclear division synaptonemal complex assembly reciprocal meiotic recombination male meiosis I spermatogenesis spermatid development fertilization seminiferous tubule development chromosome segregation synapsis meiotic cell cycle

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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REC8 Polyclonal Antibody

REC8 Antibody (10793-1-AP) in WB

Product Details

10793-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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