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Invitrogen
RFTN1 Polyclonal Antibody
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Product Details
PA5-37032
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 475-520 of human Raftlin
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2553874
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 63 kDa.
Purity is >95% by SDS-PAGE.
Target Information
Raftlin, also known as RFTN1 (raftlin, lipid raft linker 1), cell migration-inducing gene 2 protein, PIB10, PIG9 or MIG2, is a 578 amino acid cell membrane protein and lipid anchor that is essential for raft cell assembly and maintenance. A member of the raftlin family, Raftlin modulates B-cell antigen receptor-mediated signaling, TCR signals, and is involved in T cell-mediated immune responses. The gene encoding Raftlin maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cell migration-inducing gene 2 protein; proliferation-inducing protein 10; proliferation-inducing protein 9; Raft-linking protein; Raftlin
Gene Aliases: 2310015N21Rik; AI853526; KIAA0084; MIG2; PIB10; PIG9; RAFTLIN; RFTN1; RGD1310777; RGD1563347
UniProt ID: (Human) Q14699, (Mouse) Q6A0D4
Entrez Gene ID: (Human) 23180, (Rat) 501095, (Mouse) 76438
membrane raft assembly
T cell antigen processing and presentation
protein transport into membrane raft
interleukin-17 production
dsRNA transport
toll-like receptor 3 signaling pathway
growth
response to exogenous dsRNA
T cell receptor signaling pathway
B cell receptor signaling pathway
protein localization to membrane raft
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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