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Product Details
PA5-57492
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RGL4. Recombinant protein control fragment (Product #RP-91551).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2646509
Product Specific Information
Immunogen sequence: KLLTNLPAAA VLSAQVYSAV LRGLWEENVC GTPGRTRVCT ALLYGQVCPF QDSTDGLRTI TSILFNWPPE NTSVYYQPPQ RSSFRIKLAF RNLSWPGLGL EDHQEIVLGQ LVLPEPNEAK PDDPAPRPGQ HAL
Highest antigen sequence identity to the following orthologs: Mouse - 20%, Rat - 20%.
Target Information
Ral Guanine Nucleotide Dissociation Stimulator-Like 4 (RGL4) is a gene that encodes a member of the RalGDS family, which is involved in the regulation of the Ras signaling pathway. This gene is located on chromosome 22 and is highly expressed in various tissues, including the brain and reproductive organs. RGL4 is known to interact with RalA and RalB, small GTPases that play crucial roles in cellular processes such as vesicular trafficking, cytoskeleton dynamics, and cell proliferation. Studies have shown that the expression of RGL4 has significant implications in various cancers. For instance, low expression of RGL4 is associated with poor prognosis and increased immune infiltration in lung adenocarcinoma (LUAD). Conversely, overexpression of RGL4 has been correlated with resistance to Midostaurin in FLT3-ITD mutant acute myeloid leukemia (AML) samples. These findings highlight the gene's potential as a biomarker for prognosis and therapy response in certain cancers, making it a valuable target for further research and clinical applications.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hRGR; Ral guanine nucleotide dissociation stimulator-like 4; Ral-GDS related protein Rgr; Ral-GDS-related protein; RalGDS related oncogene; RalGDS-like 4
Gene Aliases: RGL4; RGR
UniProt ID: (Human) Q8IZJ4
Entrez Gene ID: (Human) 266747
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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