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Immunogen sequence: MAETSALPT GFGELEVLAV GMVLLVEDPG AADSLPPTGA ELGSCGQWDQ PECPRCSHIQ PSPCLPQALA LRLGRLPGSR LPGLCDSVGQ HLQQCSHRMG ALSPLLHPPK CCHRSHHFEW R (1-120 aa encoded by BC008094)
This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms.
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Protein Aliases: RGR opsin; RGR-opsin; RPE retinal G-protein coupled receptor; RPE-retinal G protein-coupled receptor
Gene Aliases: RGR; RP44
UniProt ID: (Human) P47804, (Mouse) Q9Z2B3
Entrez Gene ID: (Human) 5995, (Mouse) 57811, (Rat) 306307
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