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Product Details
H00005996-D01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RGS1 (AAH15510.1, 1 a.a. approximately 196 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MPGMFFSANP KELKGTTHSL LDDKMQKRRP KTFGMDMKAY LRSMIPHLES GMKSSKSKDV LSAAEVMQWS QSLEKLLANQ TGQNVFGSFL KSEFSEENIE FWLACEDYKK TESDLLPCKA EEIYKAFVHS DAAKQINIDF RTRESTAKKI KAPTPTCFDE AQKVIYTLME KDSYPRFLKS DIYLNLLNDL QANSLK
Target Information
This gene encodes a member of the regulator of G-protein signaling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-cell activation protein BL34; Early response protein 1R20; epididymis secretory protein Li 87; immediate-early response 1, B-cell specific; Regulator of G-protein signaling 1; regulator of G-protein signalling 1; RGS1
Gene Aliases: 1R20; BL34; HEL-S-87; IER1; IR20; RGS1
UniProt ID: (Human) Q08116
Entrez Gene ID: (Human) 5996
immune response
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
regulation of G-protein coupled receptor protein signaling pathway
negative regulation of signal transduction
positive regulation of GTPase activity
leukotriene signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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